{"id":"W1992575516","doi":"10.1074/jbc.m701735200","title":"Residues 334 and 338 in Transmembrane Segment 8 of Human Equilibrative Nucleoside Transporter 1 Are Important Determinants of Inhibitor Sensitivity, Protein Folding, and Catalytic Turnover","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Wellcome Trust","keywords":"Nucleoside transporter; Nucleoside; Transporter; Chemistry; Transmembrane protein; Sensitivity (control systems); Folding (DSP implementation); Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008315541,0.0005021809,0.0002722525,0.0001104904,0.0001652902,0.0001870968,0.000182504,0.0003765278,0.00188002],"category_scores_gemma":[0.0001915823,0.0001049882,0.0002741134,0.0001200261,0.0001522917,0.0001968679,0.000135505,0.000409013,0.00071464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003611281,"about_ca_system_score_gemma":0.0001831199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001038434,"about_ca_topic_score_gemma":0.0008513242,"domain_scores_codex":[0.999912,0.000019225,0.000007824285,0.00001738491,0.00002600108,0.0000174725],"domain_scores_gemma":[0.9999018,0.00002160336,0.00003762688,0.000005680684,0.00001131028,0.00002188766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003348275,0.00002968004,0.00100491,0.00003804964,0.000009300149,0.0006657258,0.00002441027,0.0002481203,0.9951023,0.0002236677,0.0001236607,0.002195241],"study_design_scores_gemma":[0.0001688209,0.001021586,0.06674154,0.00004045901,0.000088527,0.009565081,0.0001359726,0.006070691,0.9002305,0.0004349061,0.01545196,0.00004999119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953347,0.000731909,0.002064544,0.0001707826,0.00002512566,0.00002365101,0.0005552017,0.00005467054,0.001039446],"genre_scores_gemma":[0.9942777,0.0003758284,0.002360114,0.00008681585,0.00001107749,0.00002049105,0.001125834,0.00001272617,0.001729455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00188002,"threshold_uncertainty_score":0.006289303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558581397680397,"score_gpt":0.2628171571725148,"score_spread":0.2472313431957108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}