{"id":"W1992581455","doi":"10.1038/sj.onc.1207948","title":"Does the reservoir for self-renewal stem from the ends?","year":2004,"lang":"en","type":"review","venue":"Oncogene","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"National Institute on Aging; National Institutes of Health","keywords":"Telomere; Biology; Telomerase; Stem cell; Stem cell theory of aging; Progenitor cell; Cell biology; Cell division; Cancer stem cell; Progenitor; Cellular differentiation; Cell; Genetics; Stem cell factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00140447,0.001099588,0.002689203,0.001616002,0.0005598483,0.002306548,0.001529113,0.003055159,0.003394331],"category_scores_gemma":[0.001427492,0.0003519865,0.0003839347,0.002255746,0.001546054,0.00410751,0.0008421299,0.003078497,0.003028346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001039958,"about_ca_system_score_gemma":0.001513573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009450052,"about_ca_topic_score_gemma":0.002755254,"domain_scores_codex":[0.9997367,0.00005344497,0.0000376784,0.00004868114,0.00009898548,0.00002447526],"domain_scores_gemma":[0.9992989,0.0004036779,0.00007772607,0.00002909967,0.0001374748,0.00005310526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001837734,0.00006214724,0.0003519075,0.009115555,0.00009561782,0.0004462513,0.0001595343,0.0004000028,0.003631007,0.01263528,0.04510483,0.9278141],"study_design_scores_gemma":[0.00002354108,0.00005295355,0.0005151661,0.001929521,0.00006367741,0.001132377,0.0002110894,0.00007210423,0.0005309992,0.006686855,0.9887642,0.00001749381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006585644,0.9983119,0.000111532,0.0006722925,0.0003157286,0.000001267125,0.000004982945,0.000004280285,0.0005121055],"genre_scores_gemma":[0.0005397021,0.9979271,0.0001199675,0.0003984399,0.0003686642,0.000003526965,0.000009423808,9.898256e-7,0.000632073],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003394331,"threshold_uncertainty_score":0.01135516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07126218057722622,"score_gpt":0.3480413575171575,"score_spread":0.2767791769399313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}