{"id":"W1992594173","doi":"10.1002/hep.26253","title":"Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis","year":2013,"lang":"en","type":"article","venue":"Hepatology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, Vanderbilt University; Ministry of Education, Science and Technology; McGill University; National Research Foundation of Korea; National Research Foundation; Vanderbilt University","keywords":"EPH receptor A2; Cancer research; MAPK/ERK pathway; Erythropoietin-producing hepatocellular (Eph) receptor; mTORC1; Metastasis; Signal transduction; Growth factor; Growth factor receptor; Protein kinase B; Transforming growth factor; Biology; Tumor progression; Chemistry; Cell biology; Cancer; Medicine; Receptor; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242196,0.0002177538,0.0004515725,0.00008993963,0.00004985089,0.00001063799,0.0001534554,0.0002824308,0.0001603556],"category_scores_gemma":[0.0001774741,0.0002120952,0.00008517363,0.0001048038,0.0002551722,0.00001810788,0.00007856147,0.00007021886,0.000002094287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001614894,"about_ca_system_score_gemma":0.00005717668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003655939,"about_ca_topic_score_gemma":0.000008206161,"domain_scores_codex":[0.9986419,0.0001247216,0.0003960078,0.00043683,0.0001123286,0.0002882068],"domain_scores_gemma":[0.9990484,0.0000962573,0.0002662122,0.0002350495,0.0002483148,0.0001057251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001706649,0.00004247501,0.0970217,0.0001468416,0.0001475362,2.345775e-7,0.0001084862,1.756065e-7,0.8891125,0.00006496761,0.01278893,0.000395506],"study_design_scores_gemma":[0.001404236,0.000515002,0.009570467,0.00001230027,0.00003716065,0.000006892467,0.0000458485,0.0001303095,0.9815649,0.000170796,0.006324369,0.0002177475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994988,0.001118685,0.002122049,0.000447893,0.00009620948,0.0004615968,0.0006948636,0.00001199797,0.00005874312],"genre_scores_gemma":[0.9950681,0.0002044895,0.003465404,0.000351271,0.00006039944,0.00008545725,0.0006852644,0.00003483345,0.00004480531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09245238,"threshold_uncertainty_score":0.864899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064440574484908,"score_gpt":0.2514364136625465,"score_spread":0.2307920079176975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}