{"id":"W1992601419","doi":"10.1002/jgm.288","title":"Antisense <i>MBD2</i> gene therapy inhibits tumorigenesis","year":2002,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Carcinogenesis; Transfection; Demethylase; Sense (electronics); Biology; DNA methylation; Cancer research; Molecular biology; Antisense RNA; Genetic enhancement; Viral vector; Vectors in gene therapy; Gene; Gene expression; Chemistry; Epigenetics; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009334426,0.000150144,0.0002282333,0.00006876984,0.00009919362,0.000007031235,0.0002451469,0.00007547664,0.0001076145],"category_scores_gemma":[0.0001253231,0.00008634798,0.0000868491,0.0001446677,0.0001284788,0.000003705309,0.00002801531,0.000119993,0.000008300807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001139978,"about_ca_system_score_gemma":0.00002658343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001053226,"about_ca_topic_score_gemma":0.000003025664,"domain_scores_codex":[0.9987586,0.000168375,0.0004503084,0.0001160075,0.0003196592,0.0001870421],"domain_scores_gemma":[0.9989456,0.00004203813,0.0003436017,0.0003124109,0.0002468441,0.0001095259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009315081,0.00004566953,0.0005038062,0.00000291856,0.00005927674,0.00001006027,0.000229204,0.0001238471,0.985139,0.00000210643,0.003268151,0.01052283],"study_design_scores_gemma":[0.001200243,0.001203854,0.001752137,0.0000194752,0.00005159232,0.0001975491,0.00006307457,0.00004492529,0.9631406,0.00007523056,0.0321476,0.0001037118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9315827,0.06312397,0.002382159,0.001795565,0.0004252343,0.00009451486,0.000002592216,0.000003306842,0.000589909],"genre_scores_gemma":[0.944256,0.05198258,0.0005583396,0.0006177233,0.002002794,9.187108e-7,0.000006195238,0.00002356356,0.0005518891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02887945,"threshold_uncertainty_score":0.3521168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02609147947076873,"score_gpt":0.2560735300985959,"score_spread":0.2299820506278272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}