{"id":"W1992613793","doi":"10.1152/ajpcell.00205.2005","title":"TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage","year":2005,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"TRPM2; Poly ADP ribose polymerase; Programmed cell death; Oxidative stress; Viability assay; Apoptosis; Cell biology; Caspase; Intracellular; Biology; Chemistry; Molecular biology; Biochemistry; Transient receptor potential channel; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156338,0.0004302402,0.0003924858,0.0002422324,0.0002945269,0.0005859067,0.0003272778,0.0007053327,0.0009369177],"category_scores_gemma":[0.0002420636,0.0001467875,0.0005010857,0.0003130638,0.0002874501,0.0004130951,0.0002245626,0.0007002935,0.0004897799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004079549,"about_ca_system_score_gemma":0.0001893729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000156986,"about_ca_topic_score_gemma":0.000137811,"domain_scores_codex":[0.9998103,0.00003165387,0.00001506355,0.00004601835,0.00005112182,0.00004590465],"domain_scores_gemma":[0.9998755,0.00001432686,0.00005343318,0.00001202496,0.00001900662,0.00002570318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000270893,0.00004622877,0.000421234,0.0001110943,0.00001655767,0.0003130462,0.00002329597,0.00008849683,0.9956347,0.0002208594,0.0002982416,0.002555345],"study_design_scores_gemma":[0.0001421424,0.001043284,0.01223088,0.00002698458,0.0000738871,0.005352826,0.00009625416,0.002459437,0.9621857,0.0004197907,0.01594323,0.00002569223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560038,0.01497802,0.02102743,0.0008054762,0.0002885367,0.0001895302,0.002044055,0.0007244748,0.003938674],"genre_scores_gemma":[0.9843478,0.004379986,0.006626148,0.0003203366,0.00008717111,0.000147401,0.001719436,0.00004456827,0.002327135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009369177,"threshold_uncertainty_score":0.00313431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03313532604334292,"score_gpt":0.2682164203860741,"score_spread":0.2350810943427312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}