{"id":"W1992622710","doi":"10.1016/j.celrep.2014.10.044","title":"Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Partenariat Canadien Contre Le Cancer; FP7 Health; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Cell biology; Neurodegeneration; Signal transduction; Biology; Effector; Regulator; Inflammation; Immunology; Gene; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005732561,0.000168402,0.0001685316,0.00005500549,0.00006762228,0.00002812601,0.0000704187,0.0002205119,0.000008832493],"category_scores_gemma":[0.0002361538,0.0001773976,0.00006365124,0.00009506725,0.00003824196,0.00001245811,0.00007521512,0.000166041,0.000008624488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004256615,"about_ca_system_score_gemma":0.00007721243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002303238,"about_ca_topic_score_gemma":0.0001187598,"domain_scores_codex":[0.998611,0.00005812159,0.0004075087,0.0005421982,0.0001653095,0.0002158074],"domain_scores_gemma":[0.9988567,0.0000302861,0.0003876093,0.0005941293,0.000073296,0.00005795003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002674402,0.00003892233,0.00607705,0.00001061672,0.00001171281,0.00005560824,0.000055587,0.004240517,0.9858516,0.000008295439,0.00007019143,0.003312437],"study_design_scores_gemma":[0.0005480191,0.0001360778,0.0439584,0.00003004748,0.00001894522,0.00001946329,0.00002046833,0.001611951,0.9499974,0.001073609,0.002370826,0.0002147464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923785,0.0001184346,0.004128464,0.00002806833,0.0004564849,0.0001915195,0.000006113101,0.00003143372,0.002660924],"genre_scores_gemma":[0.9986501,0.00001197963,0.0004183784,0.00002511937,0.0003135215,0.00002158471,0.0003151048,0.00002445119,0.0002197769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03788135,"threshold_uncertainty_score":0.7234065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017101982335807,"score_gpt":0.2181210580832724,"score_spread":0.2079500382599143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}