{"id":"W1992624894","doi":"10.1097/jto.0000000000000318","title":"Patient-Reported Outcomes and Quality of Life in PROFILE 1007: A Randomized Trial of Crizotinib Compared with Chemotherapy in Previously Treated Patients with ALK-Positive Advanced Non–Small-Cell Lung Cancer","year":2014,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Pfizer","keywords":"Medicine; Crizotinib; Pemetrexed; Docetaxel; Lung cancer; Internal medicine; Quality of life (healthcare); Oncology; Performance status; ALK inhibitor; Chemotherapy; Physical therapy; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007099682,0.0001909798,0.002111244,0.0002529893,0.00001924605,0.000004210498,0.00005334543,0.00009523171,0.00002216254],"category_scores_gemma":[0.000248533,0.0001108755,0.0001158192,0.0002337139,0.000135741,0.00008784678,0.0000121629,0.00019199,6.593373e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002710641,"about_ca_system_score_gemma":0.0008068261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007054671,"about_ca_topic_score_gemma":0.000554603,"domain_scores_codex":[0.9973916,0.0005249351,0.001435019,0.0001848785,0.0002782519,0.0001853563],"domain_scores_gemma":[0.9962283,0.0005233691,0.002412198,0.000147526,0.0005673561,0.0001211956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5398309,0.002028137,0.4468692,0.0001606102,0.0006115282,0.00001144132,0.00260308,0.00007579625,0.0001581313,0.000001161312,0.000007126069,0.007642932],"study_design_scores_gemma":[0.6572297,0.007018707,0.3327221,0.0005827067,0.0008780273,0.000005594972,0.0003544817,0.0001262203,0.0009684865,0.000004522406,0.00001421545,0.00009522573],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953244,0.0002237201,0.0001115168,0.0003445561,0.00009250532,0.003351576,0.00001583891,0.00000431503,0.0005315471],"genre_scores_gemma":[0.9965681,0.00007389647,0.002962984,0.0001414452,0.00002169337,0.0001359607,0.00001888113,0.00001912886,0.00005792946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1173989,"threshold_uncertainty_score":0.452137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01542092926780004,"score_gpt":0.4012637173132929,"score_spread":0.3858427880454929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}