{"id":"W1992654744","doi":"10.1007/s10565-011-9190-x","title":"Regulation of forskolin-induced cAMP production by cytochrome P450 epoxygenase metabolites of arachidonic acid in HEK293 cells","year":2011,"lang":"en","type":"article","venue":"Cell Biology and Toxicology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Department of Higher Education and Training","keywords":"Forskolin; Epoxygenase; HEK 293 cells; Adenylyl cyclase; Arachidonic acid; Rolipram; Cyclic adenosine monophosphate; Epoxyeicosatrienoic acid; Internal medicine; Adenosine; Endocrinology; Chemistry; Biology; Phosphodiesterase; Signal transduction; Biochemistry; Enzyme; Receptor; Stimulation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003008443,0.0001737458,0.0004161504,0.0001305528,0.00004093258,0.000001242945,0.0001309347,0.0004938322,0.00008965081],"category_scores_gemma":[0.00005136372,0.0001555265,0.00006896626,0.0001096828,0.0003113898,0.000006698926,0.00009505081,0.0001373906,0.000003302748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006786594,"about_ca_system_score_gemma":0.00006205984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003861379,"about_ca_topic_score_gemma":0.00004554687,"domain_scores_codex":[0.9985618,0.0002511021,0.0004388772,0.0004397963,0.00003514101,0.0002733049],"domain_scores_gemma":[0.9993119,0.00002567794,0.0002618382,0.0002460366,0.00009191777,0.00006266344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003285196,0.0003471943,0.003420668,0.00003933247,0.00004479276,0.000001754784,0.0001103057,0.00000257332,0.9944532,0.0002868227,0.0002764367,0.0006884185],"study_design_scores_gemma":[0.0008570518,0.001099449,0.01881547,0.000004202107,0.00004346826,0.0000166381,0.00004494049,0.00001856902,0.9773041,0.0005805002,0.001071138,0.0001444826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961587,0.002698522,0.00005769222,0.00006462087,0.0002513874,0.0002920849,0.00003326627,0.000006148958,0.0004375849],"genre_scores_gemma":[0.9982879,0.0007089016,0.0004636088,0.0001743536,0.00006865938,0.00002922395,0.0001132216,0.00001351884,0.0001406242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01714909,"threshold_uncertainty_score":0.6342185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607437392289731,"score_gpt":0.2495059263056584,"score_spread":0.2334315523827611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}