{"id":"W1992654744","doi":"10.1007/s10565-011-9190-x","title":"Regulation of forskolin-induced cAMP production by cytochrome P450 epoxygenase metabolites of arachidonic acid in HEK293 cells","year":2011,"lang":"en","type":"article","venue":"Cell Biology and Toxicology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Department of Higher Education and Training","keywords":"Forskolin; Epoxygenase; HEK 293 cells; Adenylyl cyclase; Arachidonic acid; Rolipram; Cyclic adenosine monophosphate; Epoxyeicosatrienoic acid; Internal medicine; Adenosine; Endocrinology; Chemistry; Biology; Phosphodiesterase; Signal transduction; Biochemistry; Enzyme; Receptor; Stimulation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005230331,0.0003097063,0.0006944623,0.0004274422,0.0005311632,0.0009037012,0.0005136254,0.0004216587,0.002049428],"category_scores_gemma":[0.0003822104,0.0002725828,0.0006899396,0.000435445,0.0004672632,0.0004103803,0.0003271389,0.001347007,0.001159597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008833547,"about_ca_system_score_gemma":0.0004119091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001840572,"about_ca_topic_score_gemma":0.002561713,"domain_scores_codex":[0.9991776,0.0001635125,0.000121342,0.0001343115,0.0002248426,0.0001782836],"domain_scores_gemma":[0.9996432,0.0001414455,0.0000391418,0.00008384492,0.00006241025,0.00002994548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000220672,0.00005765678,0.0001439349,0.00003923666,0.000008903232,0.00006387162,0.00006341084,0.0000615196,0.9981276,0.0003045332,0.0001320555,0.000776597],"study_design_scores_gemma":[0.00002643987,0.00005550987,0.00174706,0.000004099715,0.000013795,0.00008774937,0.00004245776,0.0009843155,0.9944958,0.00005006951,0.002485765,0.000007042563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629863,0.0038963,0.01688698,0.001046342,0.0005066106,0.0002416762,0.004807982,0.0007457898,0.008882076],"genre_scores_gemma":[0.9773425,0.001660818,0.00961106,0.0002385089,0.00006606423,0.0002042652,0.003650035,0.000107776,0.007118965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049428,"threshold_uncertainty_score":0.006855965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607437392289731,"score_gpt":0.2495059263056584,"score_spread":0.2334315523827611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}