{"id":"W1992668369","doi":"10.1038/labinvest.3780083","title":"Simultaneous Quantitation of Topoisomerase II α and β Isoform mRNAs in Lung Tumor Cells and Normal and Malignant Lung Tissue","year":2000,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Cancer Institute","keywords":"Topoisomerase; Molecular biology; Biology; Messenger RNA; Lung cancer; Gene isoform; Lung; Enzyme; Gene; Pathology; Biochemistry; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098305,0.00009133776,0.00009733749,0.00003694315,0.00005574397,0.00001562178,0.00002730006,0.00006656393,0.00001121321],"category_scores_gemma":[0.00001260781,0.00009459833,0.000006608273,0.00008276629,0.0000809644,0.0000134263,0.00002086595,0.00004113588,2.952914e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009549353,"about_ca_system_score_gemma":0.00004677485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005880141,"about_ca_topic_score_gemma":0.0001185332,"domain_scores_codex":[0.9994602,0.00002844485,0.0001631159,0.0001836137,0.00006127273,0.0001033957],"domain_scores_gemma":[0.9997299,0.00001005464,0.00006079399,0.00008763107,0.00004896763,0.00006268594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004681197,0.00001256327,0.001221099,0.00007413186,0.000009062672,0.000003053305,0.0005138978,0.0001056576,0.9926506,0.0004256128,0.0000192226,0.00491832],"study_design_scores_gemma":[0.0006175091,0.0002949693,0.001633429,0.00004045183,0.00002130555,0.000006504644,0.0001452062,0.003715372,0.9886984,0.0001922822,0.0044856,0.0001490003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973781,0.002242519,0.00004586583,0.00007670245,0.00003952755,0.0001257284,0.00005340699,0.000004404079,0.00003375886],"genre_scores_gemma":[0.9980364,0.0008953837,0.0005585696,0.0003313703,0.00003233448,0.000008690023,0.00004131103,0.00001019628,0.00008569998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00476932,"threshold_uncertainty_score":0.3857608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004894728207956826,"score_gpt":0.2294014853017181,"score_spread":0.2245067570937613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}