{"id":"W1992681202","doi":"10.1523/jneurosci.5537-05.2006","title":"Motoneurons Derived from Embryonic Stem Cells Express Transcription Factors and Develop Phenotypes Characteristic of Medial Motor Column Neurons","year":2006,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; Atlantic Canada Opportunities Agency; Nova Scotia Health Research Foundation","keywords":"Biology; Cell biology; Embryonic stem cell; Sonic hedgehog; Embryoid body; Retinoic acid; Motor neuron; Homeobox; Neuroscience; Transcription factor; Cell culture; Adult stem cell; Spinal cord; Biochemistry; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548912,0.0001482899,0.0002304963,0.00009343647,0.00008764726,0.00004806723,0.0003749886,0.00007252389,0.000005643154],"category_scores_gemma":[0.00008058981,0.0001278095,0.00007824954,0.0001417019,0.0002498431,0.00002658318,0.00008573423,0.0001647521,8.126204e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001287509,"about_ca_system_score_gemma":0.0001573147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002631077,"about_ca_topic_score_gemma":0.00001055373,"domain_scores_codex":[0.9985273,0.0001451983,0.0003873661,0.000283442,0.0004076145,0.000249011],"domain_scores_gemma":[0.9991533,0.0000570645,0.0003157848,0.0001716619,0.0001698542,0.0001323161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009783666,0.00007553838,0.003411562,0.00001625237,0.000003965317,0.00001975491,0.00003847847,0.00005876171,0.9960883,0.000001230541,0.00006047926,0.0001277981],"study_design_scores_gemma":[0.0003230165,0.0004046858,0.2361727,0.00001556246,0.00001604819,0.00002536541,0.00001980495,0.0001938109,0.7616792,0.000006346099,0.001050397,0.00009304295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976512,0.000193258,0.001272456,0.00006382262,0.0005687481,0.0001380598,0.00009159988,0.000003259499,0.00001760524],"genre_scores_gemma":[0.9991876,0.0002864763,0.0001687788,0.0000471463,0.0001166546,0.000001908069,0.000004255762,0.0000154806,0.0001717146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2344091,"threshold_uncertainty_score":0.5211921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01954374925757305,"score_gpt":0.2392773111103133,"score_spread":0.2197335618527402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}