{"id":"W1992693390","doi":"10.1038/ncomms7442","title":"A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Novo Nordisk Fonden; Danmarks Frie Forskningsfond; Novo Nordisk; H. Lundbeck A/S; National Science Foundation; Lundbeckfonden; Australian Cancer Research Foundation; Australian Government; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Nod; Cytokine; Signalling; Cell biology; Production (economics); Inflammation; Signalling pathways; Medicine; Biology; Immunology; Signal transduction; Endocrinology; Diabetes mellitus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899784,0.0006372511,0.0006295668,0.0003591392,0.0001722176,0.0003631526,0.0004099319,0.000488009,0.002091544],"category_scores_gemma":[0.0001601811,0.0002127094,0.0003824213,0.0002034823,0.0003123671,0.0004821685,0.0001879873,0.001254921,0.000551252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490263,"about_ca_system_score_gemma":0.000362699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002307763,"about_ca_topic_score_gemma":0.0005195403,"domain_scores_codex":[0.9997795,0.00003011034,0.00003321526,0.00004746273,0.00005392273,0.00005580287],"domain_scores_gemma":[0.9998586,0.00002257404,0.0000379804,0.00001687229,0.00001309864,0.00005079974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006249255,0.0002215464,0.00006352171,0.000085903,0.00001750303,0.00006092144,0.000008334374,0.0000909654,0.9958445,0.0001450733,0.000181575,0.002655234],"study_design_scores_gemma":[0.0001330037,0.001205668,0.0009462915,0.000005943205,0.00002984275,0.0003423304,0.00001168447,0.00053895,0.9940766,0.00004420393,0.002657109,0.000008429013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778269,0.006707648,0.008423507,0.0005258849,0.00026845,0.0001599181,0.001163196,0.0007543984,0.004169984],"genre_scores_gemma":[0.9834951,0.002825068,0.007524787,0.0002573894,0.00005595774,0.000152304,0.001396947,0.00007104415,0.004221552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002091544,"threshold_uncertainty_score":0.00699693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600252926173033,"score_gpt":0.2747174892636705,"score_spread":0.2587149600019402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}