{"id":"W1992693390","doi":"10.1038/ncomms7442","title":"A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Novo Nordisk Fonden; Danmarks Frie Forskningsfond; Novo Nordisk; H. Lundbeck A/S; National Science Foundation; Lundbeckfonden; Australian Cancer Research Foundation; Australian Government; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Nod; Cytokine; Signalling; Cell biology; Production (economics); Inflammation; Signalling pathways; Medicine; Biology; Immunology; Signal transduction; Endocrinology; Diabetes mellitus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003446555,0.0001516309,0.0001126107,0.00006645759,0.0001891298,0.00001728062,0.0006860228,0.0003321072,0.000005047498],"category_scores_gemma":[0.0003792705,0.0001558924,0.0000817691,0.0001625213,0.00007269294,0.00001762526,0.0003872657,0.0004693074,0.00004084348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003747274,"about_ca_system_score_gemma":0.0001557135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005997569,"about_ca_topic_score_gemma":0.00009829276,"domain_scores_codex":[0.9989901,0.0001475943,0.0002557168,0.0002410627,0.0001708199,0.0001946923],"domain_scores_gemma":[0.9981891,0.00001179246,0.0001289016,0.001305892,0.0002888884,0.00007544655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001844748,0.0004761417,0.01338878,0.00002810608,0.0002196491,0.000001095955,0.0005925305,0.0002525371,0.9413475,0.0005632318,0.04065305,0.002292909],"study_design_scores_gemma":[0.001747709,0.0002759873,0.005645616,0.0001088848,0.00009040738,0.00002902768,0.0006017206,0.0002191104,0.3712447,0.000697175,0.6186823,0.0006573824],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855703,0.009254569,0.0001686831,0.001427377,0.0006242653,0.000474622,0.0000205961,0.00004814884,0.002411477],"genre_scores_gemma":[0.9958823,0.0005308455,0.001625462,0.0002208715,0.0001913945,0.00008118138,0.0007401829,0.00002813726,0.0006996096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5780292,"threshold_uncertainty_score":0.6357108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600252926173033,"score_gpt":0.2747174892636705,"score_spread":0.2587149600019402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}