{"id":"W1992733480","doi":"10.1002/art.20632","title":"Regulation of the expression of 5‐lipoxygenase–activating protein/5‐lipoxygenase and the synthesis of leukotriene B<sub>4</sub> in osteoarthritic chondrocytes: Role of transforming growth factor β and eicosanoids","year":2004,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Arachidonate 5-lipoxygenase; Leukotriene B4; Chemistry; Nitric oxide; Eicosanoid; Prostaglandin E; Prostaglandin E2; Lipoxygenase; Leukotriene; Transforming growth factor; Messenger RNA; Prostaglandin; Cyclooxygenase; Internal medicine; Endocrinology; Enzyme; Biochemistry; Inflammation; Biology; Arachidonic acid; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003329684,0.0002512178,0.0008041565,0.0001872156,0.0001069246,0.000009507922,0.000104169,0.0001486832,0.00001148085],"category_scores_gemma":[0.0004544494,0.000174422,0.0001533407,0.0003123633,0.0004752084,0.0002912898,0.00006058393,0.0001627772,3.076419e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003770969,"about_ca_system_score_gemma":0.0001344263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000258981,"about_ca_topic_score_gemma":0.0002875515,"domain_scores_codex":[0.9979089,0.0001486492,0.000955473,0.0002825929,0.0004484219,0.0002559201],"domain_scores_gemma":[0.9985691,0.0003512492,0.0005200698,0.0003426083,0.0001379657,0.00007895873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003276224,0.000135356,0.0009735373,0.0003887543,0.00002108595,0.000002286997,0.003427203,0.000007568471,0.8262021,0.002494988,2.707527e-7,0.1660192],"study_design_scores_gemma":[0.01090821,0.0006996859,0.01054819,0.01415611,0.00004434401,0.00005693185,0.001085569,0.00002063048,0.9582686,0.004076297,0.000001593384,0.0001338752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989239,0.008659141,0.00008384602,0.0001427108,0.00003882705,0.001654935,0.00006707508,0.00001554026,0.00009886632],"genre_scores_gemma":[0.996541,0.002410347,0.0008538009,0.000008593934,0.00001156995,0.0001318082,0.00000800405,0.0000320016,0.000002849133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1658854,"threshold_uncertainty_score":0.7112724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005185355558506004,"score_gpt":0.1926809657657955,"score_spread":0.1874956102072896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}