{"id":"W1992748173","doi":"10.1038/ncomms7404","title":"The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":372,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institutes of Health Research; Simons Foundation; Howard Hughes Medical Institute; Simons Foundation Autism Research Initiative; Yale University","keywords":"Chromodomain; Autism; Biology; Neuroscience; Chromatin; Gene knockdown; Gene; Human brain; Autism spectrum disorder; Genetics; Medicine; Psychiatry; Helicase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005814165,0.0001269861,0.0001115043,0.0003162599,0.0001347008,0.0001935737,0.000116461,0.0001200063,0.0008335781],"category_scores_gemma":[0.0001377191,0.00009337475,0.00009288942,0.0001133685,0.0001625757,0.00009925622,0.0001895827,0.000134814,0.0001661837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776204,"about_ca_system_score_gemma":0.0001316022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384729,"about_ca_topic_score_gemma":0.002533076,"domain_scores_codex":[0.9999413,0.000004222772,0.000002357164,0.00002120964,0.00001955523,0.00001132334],"domain_scores_gemma":[0.9999367,0.00001078859,0.00002158309,0.000005277499,0.000009978449,0.0000156973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001638057,0.00001035284,0.01050552,0.00002209784,0.000007593503,0.000126666,0.00006641675,0.0001631628,0.9830376,0.0002768088,0.0001037757,0.005516134],"study_design_scores_gemma":[0.00002070784,0.000125828,0.4061582,0.00001182734,0.00003147113,0.0007980654,0.000155257,0.002541237,0.5851903,0.0005525723,0.004403922,0.00001062895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959494,0.0007596834,0.001687595,0.00004739458,0.000006293062,0.000005257358,0.0003114415,0.00004882076,0.001184223],"genre_scores_gemma":[0.9970708,0.0003158685,0.001104044,0.00001995739,0.000002095908,0.00000774601,0.000291406,0.000009492775,0.001178658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384729,"threshold_uncertainty_score":0.002788544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05477000160040454,"score_gpt":0.3331987609012863,"score_spread":0.2784287593008817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}