{"id":"W1992781468","doi":"10.1006/abbi.2001.2320","title":"Isogloboside Biosynthesis in Metastatic R3230AC Cells Results from a Decreased GM3 Synthase Activity","year":2001,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"H2020 European Research Council; Saskatchewan Cancer Agency","keywords":"Glycosyltransferase; ATP synthase; Biosynthesis; Glycosphingolipid; Enzyme; Biology; Cell culture; Ceramide synthase; Molecular biology; Somatic cell; Biochemistry; Transfection; Cell biology; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526,0.0005638123,0.0004755598,0.0005121607,0.0002679323,0.0004815653,0.0003624897,0.000501767,0.002481871],"category_scores_gemma":[0.0001916168,0.0003225241,0.0003209644,0.0003514935,0.0003396243,0.0002896252,0.0002976711,0.001065839,0.001861738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005394534,"about_ca_system_score_gemma":0.0003634495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003473246,"about_ca_topic_score_gemma":0.002158111,"domain_scores_codex":[0.9998023,0.00002796882,0.00002126188,0.0000310444,0.00006273151,0.00005486065],"domain_scores_gemma":[0.9997488,0.00004290509,0.00004463552,0.00004839708,0.00002690664,0.00008832625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001351116,0.00001725047,0.0001163339,0.000009487583,0.000002515948,0.00007732098,0.000009025116,0.00003236392,0.9992454,0.00007825466,0.00004383589,0.000233185],"study_design_scores_gemma":[0.00003275741,0.0002257766,0.007703797,0.000002767619,0.00001076255,0.0007318666,0.00003950924,0.00097916,0.9890449,0.00009330552,0.001127949,0.000007399995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946609,0.0006853057,0.001477535,0.0001726064,0.00003171662,0.00002342081,0.001356223,0.0001844983,0.001407834],"genre_scores_gemma":[0.9917877,0.0003013481,0.001287876,0.00005589845,0.00001060025,0.0000388904,0.002705248,0.00007764625,0.003734775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003473246,"threshold_uncertainty_score":0.008302689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272107648337995,"score_gpt":0.2539019670020015,"score_spread":0.2411808905186216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}