{"id":"W1992792480","doi":"10.1158/1538-7445.am2011-lb-209","title":"Abstract LB-209: Expression of O6-methylguanine DNA-methyltransferase is regulated by Wnt/β-catenin signalling in cancer cells: A new strategy for DNA alkylators in cancer therapy","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Temozolomide; Cancer research; Wnt signaling pathway; DNA methyltransferase; Methyltransferase; Biology; DNA repair; O-6-methylguanine-DNA methyltransferase; Cancer; Clonogenic assay; Molecular biology; Cell culture; DNA; Glioma; Signal transduction; Cell biology; Methylation; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000885814,0.000285863,0.0002575923,0.0002479281,0.0001716682,0.0003911973,0.0001467347,0.0002586076,0.002163845],"category_scores_gemma":[0.00005984197,0.0001239659,0.0002475914,0.0003465888,0.0001738134,0.0002132557,0.0001687739,0.0006522373,0.000846044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004930632,"about_ca_system_score_gemma":0.0002736726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142317,"about_ca_topic_score_gemma":0.001735512,"domain_scores_codex":[0.9998838,0.0000102302,0.00001076109,0.00002544348,0.0000460834,0.00002362841],"domain_scores_gemma":[0.9999516,0.000004344125,0.00001612632,0.000004685594,0.000009576978,0.00001375996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005303364,0.00001100688,0.0001457397,0.00002983825,0.000002520092,0.00001911346,0.0000036438,0.00001368971,0.9987271,0.00005891377,0.00007427467,0.0008611454],"study_design_scores_gemma":[0.00001480915,0.0001436091,0.005565029,0.000008450109,0.00002400269,0.0001881105,0.00002583375,0.0005665828,0.9871069,0.00004804085,0.006305162,0.000003434911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706079,0.01048357,0.008501147,0.0007278843,0.0001274845,0.00008507505,0.003295211,0.000433943,0.005737689],"genre_scores_gemma":[0.9727389,0.004438729,0.00412361,0.0001771682,0.00002535479,0.00007371411,0.00469988,0.00005518826,0.01366745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002163845,"threshold_uncertainty_score":0.007238805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1307711001998129,"score_gpt":0.401140693890934,"score_spread":0.2703695936911211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}