{"id":"W1992879610","doi":"10.1016/j.yjmcc.2007.08.003","title":"Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute","keywords":"Biliverdin; Heme oxygenase; Biliverdin reductase; Chemistry; PI3K/AKT/mTOR pathway; Hypoxia (environmental); Protein kinase B; Heme; Biochemistry; Enzyme; Oxygen; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002770685,0.0004613894,0.0004414473,0.0002767628,0.0003695244,0.0003324803,0.0004031924,0.0003309112,0.002438734],"category_scores_gemma":[0.0001808225,0.0002819359,0.0003994148,0.0001493741,0.0002672776,0.0003984236,0.0003159115,0.001108683,0.0004192558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004130715,"about_ca_system_score_gemma":0.0003162442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006432682,"about_ca_topic_score_gemma":0.0006989651,"domain_scores_codex":[0.9998379,0.00002874917,0.00000982334,0.00002808716,0.00002268407,0.00007290127],"domain_scores_gemma":[0.9998735,0.00001304503,0.00003910559,0.00002185586,0.0000175098,0.00003493612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002420165,0.0001811387,0.0003621339,0.000148553,0.00004050522,0.0001960458,0.00003462077,0.00007011139,0.9912699,0.0005641275,0.0003534609,0.004359119],"study_design_scores_gemma":[0.0004217733,0.0008944439,0.04651859,0.00003585004,0.0001116981,0.0008310601,0.00007705942,0.002029046,0.9434337,0.0006333838,0.004991984,0.0000214771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811776,0.009138007,0.004475506,0.0009328872,0.0001994896,0.00008883815,0.0003993158,0.0002788541,0.003309518],"genre_scores_gemma":[0.9927444,0.001553628,0.001193047,0.0001051293,0.0000310151,0.00007101972,0.0004553054,0.00001864418,0.003827805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002438734,"threshold_uncertainty_score":0.008158326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236492672264222,"score_gpt":0.2253067000850878,"score_spread":0.2129417733624456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}