{"id":"W1992895388","doi":"10.1371/journal.pone.0039764","title":"Irinotecan (CPT-11) Chemotherapy Alters Intestinal Microbiota in Tumour Bearing Rats","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Foundation of Canada; Canada Research Chairs; Crohn's and Colitis Foundation","keywords":"Irinotecan; Gut flora; Microbiology; Biology; Antibiotics; Toxicity; Pharmacology; Chemotherapy; Glutamine; Internal medicine; Colorectal cancer; Gastroenterology; Immunology; Medicine; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001425013,0.0001409433,0.0001486996,0.00004800286,0.00003407663,0.00001771309,0.0001489525,0.00008689364,0.00004174398],"category_scores_gemma":[0.00001181067,0.0001501658,0.00004743744,0.0000745704,0.00003010859,0.00000437453,0.000067917,0.0001039085,0.00001377508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003703271,"about_ca_system_score_gemma":0.000035693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006205629,"about_ca_topic_score_gemma":0.00008261913,"domain_scores_codex":[0.9991435,0.00002286193,0.0001512294,0.0002194335,0.00009607572,0.0003669363],"domain_scores_gemma":[0.9995924,0.000005305379,0.0000516788,0.0002238911,0.00003220773,0.00009448819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006015281,0.000607196,0.005005665,0.00002227467,0.00005381696,0.000001034215,0.00008697881,0.000002017086,0.9930111,0.00005991363,0.00006261716,0.001027211],"study_design_scores_gemma":[0.0005498547,0.000162511,0.003534359,0.00006680198,0.00002048143,0.000006655299,0.00003263435,0.00003079227,0.9928485,0.00002586205,0.002528639,0.0001929278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982039,0.0005952976,0.0003154118,0.0002967097,0.00007943551,0.0001706401,0.00000608461,0.00001335588,0.0003191241],"genre_scores_gemma":[0.9953155,0.0001837778,0.00285275,0.0008123252,0.0003586199,0.00002100638,0.00002841552,0.00003463596,0.0003929626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002888434,"threshold_uncertainty_score":0.6123582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03334550224047823,"score_gpt":0.2424705780979383,"score_spread":0.2091250758574601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}