{"id":"W1992908365","doi":"10.1007/s11095-014-1524-y","title":"Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine:An Intracerebral Microdialysis Study in Conscious Rats","year":2014,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Pfizer Canada; National Institutes of Health; National Institute for Health and Care Research","keywords":"Microdialysis; Quinidine; Calcitriol receptor; P-glycoprotein; Internal medicine; Endocrinology; Pharmacology; Chemistry; Efflux; Blood–brain barrier; CYP3A; Extracellular; Receptor; Pregnane X receptor; Pharmacokinetics; Cytochrome P450; Medicine; Metabolism; Central nervous system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002766858,0.0006987792,0.000775162,0.0005199757,0.0005274155,0.0005131774,0.0005589257,0.0006346254,0.001230574],"category_scores_gemma":[0.0003389888,0.0005153028,0.000732914,0.0003428325,0.001240913,0.001024859,0.0002928818,0.001853514,0.0002570621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008983065,"about_ca_system_score_gemma":0.000743805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006535369,"about_ca_topic_score_gemma":0.009749211,"domain_scores_codex":[0.9996434,0.00004653714,0.00002404916,0.00009525772,0.000071022,0.0001196946],"domain_scores_gemma":[0.9995412,0.00007886565,0.0001167108,0.00009486334,0.0000459116,0.0001226383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01025643,0.0005148598,0.000682571,0.00005410264,0.00006061139,0.0002492139,0.0001391491,0.0000696237,0.985375,0.0002707047,0.000139779,0.002188015],"study_design_scores_gemma":[0.0003247791,0.004096353,0.009961151,0.000004670779,0.0001840991,0.0003142327,0.0002021579,0.001043949,0.9830428,0.0001909116,0.0006018461,0.00003309509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964155,0.00068172,0.001870822,0.0001840907,0.00004481902,0.00003475886,0.0002770638,0.00006172138,0.0004295118],"genre_scores_gemma":[0.9932474,0.001074164,0.002490503,0.00009180062,0.0000530027,0.00009196114,0.0003625343,0.00003235636,0.002556259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006535369,"threshold_uncertainty_score":0.01299471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1131149301862051,"score_gpt":0.4696087167547677,"score_spread":0.3564937865685627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}