{"id":"W1992918548","doi":"10.1002/cam4.146","title":"<scp>BRD</scp>4 associates with p53 in <scp>DNMT</scp>3A‐mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor <scp>JQ</scp>1","year":2013,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Bromodomain; BET inhibitor; Cancer research; Daunorubicin; Apoptosis; Myeloid leukemia; Biology; Epigenetics; Acetylation; Chromatin; Leukemia; Molecular biology; Chemistry; DNA; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082993,0.0002918839,0.0002716691,0.0003755775,0.0002801974,0.0003238163,0.000235009,0.0002865097,0.002191242],"category_scores_gemma":[0.0001163319,0.0002681232,0.0003282493,0.0002940945,0.0002644682,0.0001771989,0.0001924819,0.0004665662,0.0008298089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007404407,"about_ca_system_score_gemma":0.0002643129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002203189,"about_ca_topic_score_gemma":0.002925961,"domain_scores_codex":[0.9997694,0.00002708602,0.00001303683,0.00004234226,0.0001054368,0.0000426643],"domain_scores_gemma":[0.9998926,0.00001694701,0.00003747259,0.00001513715,0.00001026789,0.00002763864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006106713,0.00001216563,0.0003107921,0.00001836583,0.000008980374,0.00004479204,0.000004965477,0.00002164327,0.9991394,0.00001979236,0.00002902917,0.0003289767],"study_design_scores_gemma":[0.00002786114,0.0002086191,0.02746018,0.000005065942,0.00001888413,0.0006775477,0.00001904967,0.0007192505,0.9681321,0.00003308375,0.002694514,0.000003935619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940175,0.002582293,0.001344637,0.0001435038,0.00002055542,0.00001984451,0.000487022,0.00007257046,0.001312052],"genre_scores_gemma":[0.9932255,0.000954284,0.001081813,0.00006643293,0.00001077379,0.00003062126,0.001692517,0.00001925051,0.002918741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002203189,"threshold_uncertainty_score":0.007330418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006214205428617146,"score_gpt":0.2277778899879575,"score_spread":0.2215636845593404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}