{"id":"W1992950258","doi":"10.1074/jbc.275.18.13727","title":"Export from the Endoplasmic Reticulum Represents the Limiting Step in the Maturation and Cell Surface Expression of the Human δ Opioid Receptor","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; AstraZeneca (Canada)","funders":"","keywords":"Endoplasmic reticulum; Golgi apparatus; Glycosylation; Receptor; Cell biology; N-linked glycosylation; Secretory pathway; G protein-coupled receptor; Chemistry; Opioid receptor; Glycan; Biochemistry; Biology; Glycoprotein; Opioid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048891,0.0001794967,0.0002716403,0.0001017828,0.0001233935,0.0006607528,0.0001417313,0.0001948802,0.0006512568],"category_scores_gemma":[0.0002139718,0.000177082,0.0002543055,0.00009184462,0.0001104485,0.0004040593,0.0001734685,0.0005112862,0.0008991606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003319343,"about_ca_system_score_gemma":0.0003584992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001014326,"about_ca_topic_score_gemma":0.0006450363,"domain_scores_codex":[0.9998703,0.00001518307,0.00001941389,0.00003767309,0.0000333089,0.00002414237],"domain_scores_gemma":[0.9998413,0.00002951643,0.00003761625,0.00002069962,0.00004843939,0.0000223497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001687203,0.000008021859,0.001032853,0.0000443657,0.000004183907,0.00008745991,0.00004377713,0.00006425285,0.9951755,0.0002509383,0.00004917683,0.00307075],"study_design_scores_gemma":[0.00001588883,0.0002168714,0.02719817,0.00002692803,0.0000281454,0.000858872,0.0002409107,0.002029346,0.9622099,0.0001928232,0.006967786,0.00001427313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854378,0.005053899,0.007616509,0.0001563461,0.00003190576,0.00001657669,0.0003586311,0.00008187941,0.001246373],"genre_scores_gemma":[0.9865646,0.003663269,0.00535827,0.00009810851,0.00001594967,0.00002411939,0.0008736856,0.00004437051,0.003357614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001014326,"threshold_uncertainty_score":0.002408385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415465369180672,"score_gpt":0.2304302047950044,"score_spread":0.2162755511031977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}