{"id":"W1992956599","doi":"10.1038/nature09408","title":"Structure of a cation-bound multidrug and toxic compound extrusion transporter","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":274,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Light Source","keywords":"Transporter; Efflux; Metabolite; Multiple drug resistance; ATP-binding cassette transporter; Biology; Transport protein; Membrane transport protein; Biochemistry; Protein structure; Bacteria; Vibrio cholerae; Chemistry; Genetics; Gene; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002183828,0.0003359834,0.0007498426,0.0001906555,0.000937692,0.001263691,0.0009073297,0.001615351,0.00146149],"category_scores_gemma":[0.0002458104,0.0002740262,0.0003577285,0.0002610882,0.000558008,0.00135628,0.0003277077,0.001404624,0.0007391178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001310264,"about_ca_system_score_gemma":0.000691029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104023,"about_ca_topic_score_gemma":0.0005932146,"domain_scores_codex":[0.9999337,0.00001272061,0.000005851204,0.00001529376,0.00001615278,0.00001626735],"domain_scores_gemma":[0.9998934,0.00001500473,0.00002627106,0.000007734528,0.0000173729,0.0000402416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003389063,0.0007263008,0.002864546,0.000887654,0.0002208307,0.007458202,0.0005730573,0.02485595,0.797235,0.1248713,0.00866928,0.02824886],"study_design_scores_gemma":[0.0007740462,0.004668414,0.01213969,0.0002893006,0.0003689782,0.01037806,0.001132586,0.290726,0.4951775,0.05650221,0.1273496,0.0004936251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533934,0.01100586,0.01771427,0.006703745,0.0004099033,0.0001093559,0.0004373292,0.0004135378,0.009812563],"genre_scores_gemma":[0.9766594,0.005567443,0.006599483,0.0007219584,0.0001309539,0.00003412862,0.001177674,0.00003043468,0.009078341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001615351,"threshold_uncertainty_score":0.009506643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003899589865173013,"score_gpt":0.2423160696720217,"score_spread":0.2384164798068487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}