{"id":"W1992964343","doi":"10.4161/epi.5.8.13045","title":"Regulating a master regulator","year":2010,"lang":"en","type":"review","venue":"Epigenetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"MyoD; Biology; Psychological repression; Regulator; MyoD Protein; Promoter; Regulation of gene expression; Transcription factor; Transcriptional regulation; Genetics; PITX2; Cell biology; Gene expression; Gene; Homeobox","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004679115,0.0007693029,0.0007523122,0.0008074074,0.0002350845,0.0007510143,0.000991725,0.001260435,0.003967703],"category_scores_gemma":[0.0003715083,0.0002599065,0.0002446547,0.0006274314,0.000756253,0.001308622,0.0007510282,0.001648718,0.00431817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009919981,"about_ca_system_score_gemma":0.0006672499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004794597,"about_ca_topic_score_gemma":0.0006317969,"domain_scores_codex":[0.9998443,0.00002417199,0.00001516628,0.00004527863,0.00005383898,0.00001724066],"domain_scores_gemma":[0.9998775,0.0000444746,0.00002305438,0.000008442327,0.00002985764,0.00001682691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001184759,0.00005319325,0.0003806691,0.006734075,0.00007997278,0.000435353,0.0001230914,0.0006059281,0.02549724,0.03181623,0.04271167,0.891444],"study_design_scores_gemma":[0.000011089,0.00002770998,0.0005052437,0.0003925879,0.00001652169,0.0006952586,0.00002097052,0.00007112904,0.002881137,0.002875893,0.9924935,0.000008968546],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005389713,0.9899994,0.001305289,0.0008721781,0.0005632064,0.000009257763,0.00004509367,0.00004011415,0.006626591],"genre_scores_gemma":[0.006905591,0.9803473,0.001427609,0.001277047,0.0006678533,0.00003246974,0.0001291883,0.00001337878,0.009199549],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003967703,"threshold_uncertainty_score":0.0132733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02367744373106034,"score_gpt":0.2792881734642634,"score_spread":0.2556107297332031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}