{"id":"W1992964343","doi":"10.4161/epi.5.8.13045","title":"Regulating a master regulator","year":2010,"lang":"en","type":"review","venue":"Epigenetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"MyoD; Biology; Psychological repression; Regulator; MyoD Protein; Promoter; Regulation of gene expression; Transcription factor; Transcriptional regulation; Genetics; PITX2; Cell biology; Gene expression; Gene; Homeobox","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001876772,0.0004932061,0.0007953582,0.00007133123,0.000098287,0.00006783647,0.0005262564,0.001003134,0.00003377992],"category_scores_gemma":[0.00006208371,0.0004558456,0.0004898063,0.000104131,0.00008973532,9.254567e-7,0.0003553543,0.0003780871,0.00007380114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002361683,"about_ca_system_score_gemma":0.0002659173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001507362,"about_ca_topic_score_gemma":0.0000201504,"domain_scores_codex":[0.9981266,0.00007544459,0.0006245377,0.0006118303,0.000159165,0.000402476],"domain_scores_gemma":[0.9982191,0.00001785913,0.0003989098,0.001152063,0.00006898513,0.0001431229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002086186,0.00002861231,0.00001178271,0.001820116,0.0001027827,0.000003097424,0.00001201623,0.000009625869,0.000917574,0.00008622216,0.00074457,0.9962615],"study_design_scores_gemma":[0.0001009097,0.0000720652,0.00000755243,0.0006135989,0.0002098055,0.00005337571,0.00000402203,0.0000376907,0.000222833,0.00006592584,0.9981,0.0005122661],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001039791,0.9960591,0.0003034399,0.000008605086,0.0005950468,0.000429003,0.00008445774,0.00001777977,0.001462755],"genre_scores_gemma":[0.00005124598,0.9859722,0.007787544,0.00004095649,0.00104576,0.00004662997,0.0006798924,0.0001697828,0.004205941],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9973554,"threshold_uncertainty_score":0.9997894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02367744373106034,"score_gpt":0.2792881734642634,"score_spread":0.2556107297332031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}