{"id":"W1992965842","doi":"10.1016/j.molcel.2011.03.006","title":"Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing","year":2011,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"URA3; Biology; Gene silencing; DNA methylation; Methylation; Epigenetics; Genetics; Position effect; Saccharomyces cerevisiae; Computational biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317252,0.0002043052,0.0001862497,0.0001935259,0.0002700617,0.0004261607,0.0002652996,0.0003189447,0.001983718],"category_scores_gemma":[0.0001409293,0.0002494512,0.0001400056,0.0001221475,0.0003236185,0.000495106,0.0004427251,0.000484091,0.000509238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007862156,"about_ca_system_score_gemma":0.0001918711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001393186,"about_ca_topic_score_gemma":0.003695066,"domain_scores_codex":[0.9998915,0.00001345069,0.000006852064,0.00003336146,0.00002783494,0.00002697863],"domain_scores_gemma":[0.9999208,0.00001842203,0.00001614389,0.00001206189,0.000008121048,0.00002441901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000106372,0.000008271817,0.000337171,0.00001975241,0.000003154683,0.00003517986,0.00001394809,0.00005849333,0.9978104,0.0005518069,0.0000369,0.001018539],"study_design_scores_gemma":[0.000007965136,0.00003111864,0.007817748,0.000002171069,0.00000693415,0.0001406704,0.00002726466,0.001210412,0.9891127,0.000139551,0.001499965,0.000003447344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893111,0.002046426,0.003884832,0.0001619257,0.00002625872,0.00001389704,0.0003303933,0.00007143369,0.004153732],"genre_scores_gemma":[0.992053,0.0002542658,0.000959293,0.00003948624,0.000005845227,0.00001100975,0.0003869134,0.00003070459,0.006259491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001983718,"threshold_uncertainty_score":0.006636262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006704460728492904,"score_gpt":0.2199594533752453,"score_spread":0.2132549926467524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}