{"id":"W1992991774","doi":"10.1002/syn.20303","title":"Psychosis pathways converge via D2High dopamine receptors","year":2006,"lang":"en","type":"review","venue":"Synapse","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":330,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas College; Douglas Mental Health University Institute; Mount Sinai Hospital; McMaster University; University of Toronto","funders":"National Institute of Mental Health","keywords":"Dopamine receptor D1; Dopamine receptor D2; Dopamine; Internal medicine; Endocrinology; Pharmacology; Dopamine receptor D3; Dopamine receptor; Histamine H3 receptor; Chemistry; Phencyclidine; Receptor; Medicine; Agonist; NMDA receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002299469,0.0006247612,0.001114759,0.0001147407,0.0001078916,0.00004230758,0.000464903,0.0008718772,0.0007607255],"category_scores_gemma":[0.00003335655,0.0005240255,0.0007802915,0.0001955822,0.00006422943,0.000003239951,0.0001440829,0.0002867024,0.0002447435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004396016,"about_ca_system_score_gemma":0.0001071968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004207541,"about_ca_topic_score_gemma":0.00001206263,"domain_scores_codex":[0.9976164,0.0001756126,0.0006704174,0.0008413114,0.0002108418,0.0004853879],"domain_scores_gemma":[0.9986596,0.00002292602,0.0003760945,0.0007174743,0.00007377281,0.0001501297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002557879,0.0001702551,0.000004278188,0.00393767,0.0004725326,0.00003045805,0.000009914778,0.000001959347,0.008739214,0.0002152716,0.03851243,0.9478804],"study_design_scores_gemma":[0.0001790005,0.0002421358,1.763664e-7,0.0008419399,0.0002355203,0.00005434035,0.000003940939,0.000001781419,0.004045178,0.0000463142,0.9937332,0.0006164893],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000130154,0.9949772,0.001499523,0.000008857946,0.001576508,0.0005098935,0.0001152434,0.00004297517,0.001139589],"genre_scores_gemma":[0.0001593093,0.9926497,0.0005186325,0.00004676365,0.001068629,0.0001579943,0.002434739,0.0001347276,0.002829455],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9552208,"threshold_uncertainty_score":0.9997211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02293393204606608,"score_gpt":0.2781051202682055,"score_spread":0.2551711882221394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}