{"id":"W1992996578","doi":"10.1074/jbc.m109.074344","title":"A Role for KAI1 in Promotion of Cell Proliferation and Mammary Gland Hyperplasia by the gp78 Ubiquitin Ligase","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Ubiquitin ligase; Internal medicine; Endocrinology; Carcinogenesis; Gene knockdown; Mammary gland; Cancer research; Cancer; Ubiquitin; Apoptosis; Medicine; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003093022,0.00005929219,0.0001754875,0.00001933609,0.00002109157,0.000009656962,0.00004475901,0.0001042924,0.00004296065],"category_scores_gemma":[0.0001864387,0.00003169408,0.00007630728,0.00005647158,0.000052725,0.00003275941,0.00001185308,0.0002343711,2.001184e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000088798,"about_ca_system_score_gemma":0.00002707959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.520705e-7,"about_ca_topic_score_gemma":9.118731e-7,"domain_scores_codex":[0.9994769,0.00001540861,0.0002779618,0.00007442675,0.00008246615,0.00007291274],"domain_scores_gemma":[0.9995539,0.000052325,0.0001880958,0.00005912776,0.0000842306,0.00006236016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001362696,0.0002216541,0.01007491,0.00005797374,0.000008561899,0.000006258057,0.00002279216,2.251289e-7,0.98838,0.000003114212,0.0002532404,0.0008349571],"study_design_scores_gemma":[0.001103863,0.0002500043,0.002904333,0.00007875971,0.00002256509,0.0003239414,0.00007732086,0.0002332574,0.9943687,0.0001949545,0.0004043225,0.00003792901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978657,0.0001018949,0.00008446093,0.001486323,0.000005457227,0.0000868271,0.00001067681,0.000002920365,0.0003557667],"genre_scores_gemma":[0.9991076,0.00003704599,0.0004621545,0.0001054601,0.000124419,0.000005435342,0.00002109857,0.000002293955,0.0001344639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007170578,"threshold_uncertainty_score":0.1292447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200115474634193,"score_gpt":0.2515317632895607,"score_spread":0.2395306085432188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}