{"id":"W1993058355","doi":"10.1038/jid.2012.240","title":"Differential Effects of Neurofibromin Gene Dosage on Melanocyte Development","year":2012,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Michael Smith Health Research BC","keywords":"Neurofibromin 1; Haploinsufficiency; Biology; Neurofibromatosis; Loss of heterozygosity; Skin hyperpigmentation; Microphthalmia-associated transcription factor; Melanocyte; Cancer research; Schwann cell; Genetics; Cell biology; Hyperpigmentation; Allele; Phenotype; Gene; Melanoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009146176,0.0002039955,0.0007864478,0.0002898369,0.00005119367,0.000006551902,0.000104315,0.0001033542,0.0000420562],"category_scores_gemma":[0.0004278043,0.0001471913,0.0001741977,0.0001379354,0.0002656222,0.0001251234,0.00005033286,0.0003110124,0.00001987013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003762907,"about_ca_system_score_gemma":0.0001734647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000111281,"about_ca_topic_score_gemma":1.64021e-7,"domain_scores_codex":[0.9981925,0.0002602507,0.0007881602,0.00011796,0.0003392671,0.0003018961],"domain_scores_gemma":[0.9982132,0.0003861578,0.0007041981,0.0001617191,0.0001561517,0.0003786125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003267194,0.0003660944,0.01795119,0.0003364844,0.0002126645,0.000938981,0.0007761228,7.396279e-7,0.9762908,0.0006887112,0.001779985,0.0003315238],"study_design_scores_gemma":[0.001453801,0.0005773634,0.1853956,0.0002350929,0.0001061605,0.005934983,0.00002749975,0.000004357774,0.8053941,0.0000547365,0.0007274565,0.0000889297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978722,0.0004292901,0.0001109189,0.0006976098,0.0005221964,0.000170759,0.000002211005,0.000009857927,0.0001850027],"genre_scores_gemma":[0.9960283,0.00002262661,0.003139579,0.0006010497,0.0001455865,0.000004330273,0.00000372395,0.00002205514,0.00003273866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1708967,"threshold_uncertainty_score":0.6002287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02479327810029308,"score_gpt":0.2623749215190802,"score_spread":0.2375816434187871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}