{"id":"W1993070350","doi":"10.1160/th13-06-0490","title":"Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis","year":2013,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Canadian Blood Services; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Von Willebrand factor; Platelet; Antithrombotic; Thrombus; Glycoprotein Ib; Platelet Glycoprotein GPIb-IX Complex; Pharmacology; Intravital microscopy; Ristocetin; Platelet membrane glycoprotein; Hemostasis; Platelet adhesiveness; Thrombosis; Chemistry; In vivo; Medicine; Platelet activation; Immunology; Internal medicine; Biology; Microcirculation; Platelet aggregation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002364589,0.0006490883,0.0005621585,0.0004858051,0.000169425,0.0002798423,0.0003335226,0.0006130598,0.0009102356],"category_scores_gemma":[0.0001340158,0.0002064862,0.0003653958,0.0001800155,0.0001814492,0.0003036758,0.0001160163,0.001388439,0.0002122728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001796761,"about_ca_system_score_gemma":0.0001613731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003573547,"about_ca_topic_score_gemma":0.000695473,"domain_scores_codex":[0.9998115,0.00003966289,0.00002181186,0.00003073314,0.00005497103,0.00004145594],"domain_scores_gemma":[0.9998883,0.00001749533,0.00004019384,0.000009944376,0.000008328742,0.00003575378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000607539,0.0003334725,0.00009018857,0.00009132263,0.00001841113,0.0001017092,0.00001965455,0.0001660699,0.9935648,0.0001083604,0.000240598,0.004658001],"study_design_scores_gemma":[0.000609567,0.01250428,0.004263907,0.00003130971,0.0000966039,0.001379446,0.00002798916,0.003158463,0.9716069,0.000148666,0.006152617,0.00002033342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777647,0.008862004,0.007601657,0.0004202564,0.0002107671,0.0002038742,0.0008830317,0.0004111642,0.003642626],"genre_scores_gemma":[0.9791725,0.008414912,0.006060814,0.0002380963,0.000121833,0.0002252765,0.001817878,0.00003974934,0.003908969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009102356,"threshold_uncertainty_score":0.003045022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07177182621985079,"score_gpt":0.3003059973054338,"score_spread":0.228534171085583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}