{"id":"W1993070350","doi":"10.1160/th13-06-0490","title":"Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis","year":2013,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Canadian Blood Services; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Von Willebrand factor; Platelet; Antithrombotic; Thrombus; Glycoprotein Ib; Platelet Glycoprotein GPIb-IX Complex; Pharmacology; Intravital microscopy; Ristocetin; Platelet membrane glycoprotein; Hemostasis; Platelet adhesiveness; Thrombosis; Chemistry; In vivo; Medicine; Platelet activation; Immunology; Internal medicine; Biology; Microcirculation; Platelet aggregation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001683522,0.0002848494,0.0009377082,0.0003996338,0.00006368996,0.00003925727,0.00004759858,0.0001514028,0.00005773325],"category_scores_gemma":[0.00001788083,0.0002467231,0.00003987324,0.000375252,0.0001532246,0.0006222342,0.00009839935,0.0001576873,0.000001651946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007225996,"about_ca_system_score_gemma":0.00002288363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004217866,"about_ca_topic_score_gemma":0.00112841,"domain_scores_codex":[0.9984117,0.00003909328,0.0006084098,0.0003813818,0.0002085784,0.0003508582],"domain_scores_gemma":[0.999411,0.00008345051,0.0001487745,0.000184168,0.00005267655,0.0001198874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009621643,0.003007752,0.1215665,0.001377888,0.0002324544,0.00006597601,0.008234436,0.00006162019,0.8231788,0.0003450422,0.0005124682,0.04045485],"study_design_scores_gemma":[0.01573119,0.0004822919,0.7938302,0.0008243581,0.00009798797,0.0001041712,0.001558057,0.02175793,0.1630639,0.002082994,0.00003808764,0.0004289236],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968346,0.0005636543,0.00002888537,0.001009892,0.0000137239,0.0009600706,0.0001063936,0.00001721968,0.0004655392],"genre_scores_gemma":[0.9924219,0.005246312,0.001964639,0.0002040434,0.000006298314,0.00004384759,0.00008203505,0.0000242259,0.000006737492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6722636,"threshold_uncertainty_score":0.9999985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07177182621985079,"score_gpt":0.3003059973054338,"score_spread":0.228534171085583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}