{"id":"W1993084701","doi":"10.1111/j.1399-3089.2005.00221.x","title":"Co‐stimulation blockade targeting CD154 and CD28/B7 modulates the induced antibody response after a pig‐to‐baboon cardiac xenograft","year":2005,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; IC Design Education Center; Mayo Clinic; National Institute of Allergy and Infectious Diseases; Biogen","keywords":"Medicine; Baboon; Immunology; Blockade; Transplantation; Antibody; CD154; Anti-thymocyte globulin; Internal medicine; Biology; CD40; Receptor; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001009687,0.0003304358,0.0003809033,0.0003235847,0.0003071553,0.00008968951,0.0001028139,0.0001960479,0.0001093079],"category_scores_gemma":[0.0001035329,0.0002630442,0.0001330734,0.0004062284,0.00008305583,0.0003055742,0.000009113812,0.0003375169,0.0001516305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007618912,"about_ca_system_score_gemma":0.000090945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007381533,"about_ca_topic_score_gemma":0.00001655741,"domain_scores_codex":[0.9975737,0.000487831,0.0005703816,0.0004568776,0.0004739897,0.0004372402],"domain_scores_gemma":[0.9987099,0.000494798,0.0001180912,0.0003185406,0.0001436491,0.0002150175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01776761,0.0001009092,0.02004553,0.0001365407,0.0001159362,0.00003841886,0.01067777,0.0006546481,0.9471852,0.00002656797,0.0001222354,0.003128678],"study_design_scores_gemma":[0.002877716,0.0005179728,0.7626619,0.0002984597,0.0004413612,0.0001280402,0.0003694277,0.003252498,0.2237514,0.00001575388,0.005263466,0.0004219573],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908953,0.0006070181,0.002350083,0.004401828,0.0001558767,0.001171624,0.00009049316,0.000160934,0.0001667974],"genre_scores_gemma":[0.9956567,0.0004573055,0.001534951,0.001180312,0.0002427759,0.0000900078,0.0004567018,0.00005884848,0.0003224243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7426164,"threshold_uncertainty_score":0.9999822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128979090525256,"score_gpt":0.3057851398439651,"score_spread":0.2944953489387125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}