{"id":"W1993098682","doi":"10.1016/j.tins.2014.03.004","title":"Parkin and PINK1: much more than mitophagy","year":2014,"lang":"en","type":"review","venue":"Trends in Neurosciences","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":398,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"PINK1; Parkin; Mitophagy; Autophagy; Tensin; Biology; Mitochondrion; LRRK2; Parkinson's disease; Disease; PTEN; Genetics; Neuroscience; Cell biology; Bioinformatics; Medicine; PI3K/AKT/mTOR pathway; Pathology; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006168833,0.0009531853,0.001672056,0.0016008,0.0002752637,0.001417442,0.0007143915,0.001630134,0.003882558],"category_scores_gemma":[0.0007222084,0.0002680897,0.0003094442,0.001730647,0.000854499,0.002691548,0.001208527,0.001959161,0.00219937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007350848,"about_ca_system_score_gemma":0.001281736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005422935,"about_ca_topic_score_gemma":0.001455825,"domain_scores_codex":[0.9997954,0.00002986271,0.0000352565,0.00003674426,0.00007939032,0.00002336318],"domain_scores_gemma":[0.9997637,0.00007198485,0.000049363,0.00001066323,0.00006684676,0.00003754341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000129885,0.00003636247,0.0001381974,0.009209246,0.00009104086,0.000196328,0.0000605234,0.0001820414,0.001999611,0.006103679,0.05829278,0.9235603],"study_design_scores_gemma":[0.00001681996,0.00004047362,0.0003867362,0.001463216,0.00006371725,0.0007580487,0.00004447278,0.00004650703,0.0004107127,0.003062726,0.9936938,0.00001282884],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001221278,0.9968331,0.0002217535,0.001144087,0.0006212896,0.000002636873,0.00001935415,0.000009988403,0.001025585],"genre_scores_gemma":[0.001021144,0.9955035,0.0002538805,0.0008016238,0.000765798,0.000006097469,0.00003240722,0.000003026378,0.001612678],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003882558,"threshold_uncertainty_score":0.01298845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06801179739807535,"score_gpt":0.4158102821659929,"score_spread":0.3477984847679175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}