{"id":"W1993101822","doi":"10.1016/j.jmb.2007.01.070","title":"Evolution of Budding Yeast Prion-determinant Sequences Across Diverse Fungi","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"McGill University","keywords":"Biology; Saccharomyces cerevisiae; Genetics; Proteome; Negative selection; Yeast; Phylogenetics; Clade; Evolutionary biology; Budding yeast; Saccharomyces; Homology (biology); Molecular evolution; Gene; Computational biology; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000779209,0.0001212014,0.0002102656,0.0000802163,0.00005885729,0.00000852324,0.0002595061,0.0001778804,0.00001424034],"category_scores_gemma":[0.0001828162,0.0001025113,0.0002318261,0.00009976341,0.000134965,0.000006623768,0.000127576,0.0001087213,0.000001800657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000358578,"about_ca_system_score_gemma":0.0001128369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000186517,"about_ca_topic_score_gemma":0.000008628757,"domain_scores_codex":[0.9989001,0.00008381593,0.0004480049,0.0001642431,0.0001265821,0.0002772635],"domain_scores_gemma":[0.9989876,0.00001477979,0.0004927003,0.0001737769,0.0002201382,0.0001110034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000225312,0.00003749893,0.01276965,0.00001605257,0.00006450489,0.00005332361,0.00003648067,0.0000571776,0.9597262,0.0001705432,0.00003255847,0.02681072],"study_design_scores_gemma":[0.0007110794,0.0009211231,0.01096162,0.00006490169,0.00003690842,0.0002806157,0.0004412066,0.0000118148,0.9810942,0.0006216787,0.004676487,0.000178336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385536,0.01448477,0.04651852,0.00002778097,0.0002708507,0.000073034,0.0000196038,0.000002506704,0.00004937638],"genre_scores_gemma":[0.9966161,0.0008344026,0.002251677,0.0000592593,0.0002080486,8.319151e-7,0.000008379736,0.00001042266,0.00001092082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0580625,"threshold_uncertainty_score":0.4180289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00962755977301552,"score_gpt":0.3083132992043196,"score_spread":0.2986857394313041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}