{"id":"W1993103946","doi":"10.1089/biores.2012.0205","title":"Reovirus-Mediated Cytotoxicity and Enhancement of Innate Immune Responses Against Acute Myeloid Leukemia","year":2012,"lang":"en","type":"article","venue":"BioResearch open access","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Institute for Health and Care Research; Cancer Research UK","keywords":"Oncolytic virus; Myeloid leukemia; Immune system; Cytotoxic T cell; Innate immune system; Immunology; Chemokine; Cancer research; Degranulation; Biology; Cytokine; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002761494,0.0002394535,0.000335146,0.0002207611,0.0002041842,0.0002870006,0.002203839,0.000182052,0.000218858],"category_scores_gemma":[0.0004663727,0.0002115486,0.00007155596,0.0004750137,0.0004517425,0.0001022134,0.004125078,0.0002699707,0.00004103295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000104048,"about_ca_system_score_gemma":0.0006889956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003002771,"about_ca_topic_score_gemma":0.0001087612,"domain_scores_codex":[0.9970729,0.0005839964,0.0004273258,0.0004858583,0.0005849514,0.0008450029],"domain_scores_gemma":[0.9982722,0.00009077387,0.0001534622,0.0008228706,0.000300104,0.0003606007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008593954,0.000159862,0.008785975,0.00003939533,0.0002036516,0.000005973892,0.0000674269,9.878146e-7,0.9759137,0.00001363943,0.001147317,0.005068108],"study_design_scores_gemma":[0.00126422,0.001275244,0.02079013,0.00002839296,0.00000933663,0.000003084358,0.00004104139,0.00002122528,0.9717895,0.00001339318,0.00452278,0.0002416859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944035,0.002492036,0.00003785502,0.00027456,0.00005483971,0.001069939,0.0001609091,0.000009959319,0.001496439],"genre_scores_gemma":[0.9919109,0.005566065,0.0001744081,0.0002406049,0.0001197687,0.000196115,0.0002236836,0.00004403332,0.001524369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01200416,"threshold_uncertainty_score":0.8626701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06112472655500071,"score_gpt":0.4145932585675038,"score_spread":0.3534685320125031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}