{"id":"W1993118284","doi":"10.1089/107999003321455462","title":"CD2-CD48 Interactions Promote Cytotoxic T Lymphocyte Induction and Function: Anti-CD2 and Anti-CD48 Antibodies Impair Cytokine Synthesis, Proliferation, Target Recognition/Adhesion, and Cytotoxicity","year":2003,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Cytotoxic T cell; Perforin; CTL*; Granzyme B; Biology; Granzyme; Molecular biology; Monoclonal antibody; Fas ligand; Cell biology; CD8; Chemistry; Antibody; Immunology; Antigen; Apoptosis; In vitro; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002645025,0.0004701953,0.000915321,0.001171999,0.001022073,0.0002056979,0.0002502112,0.0004845017,0.0004835505],"category_scores_gemma":[0.001171306,0.000382754,0.000148478,0.0004976233,0.001023928,0.0009397912,0.0002053393,0.001704197,0.00007692109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338382,"about_ca_system_score_gemma":0.0003365311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006334407,"about_ca_topic_score_gemma":0.00003471994,"domain_scores_codex":[0.9954998,0.001602278,0.001199004,0.0006565448,0.0002507382,0.0007915757],"domain_scores_gemma":[0.9969738,0.0006155804,0.0005772395,0.0003517789,0.001318082,0.0001635416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001387655,0.0005363466,0.009190192,0.0001332995,0.0005162957,0.00004488686,0.0004302233,0.000003379181,0.9820485,0.0001028893,0.002027277,0.003579036],"study_design_scores_gemma":[0.002827372,0.002566308,0.01076259,0.0004823956,0.0001422265,0.006067603,0.001146361,0.00002021286,0.962259,0.0008374711,0.01248533,0.000403128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907854,0.005772592,0.000322022,0.001270585,0.0008456266,0.0005982851,0.00005380465,0.0000537331,0.0002979833],"genre_scores_gemma":[0.9914894,0.007064166,0.0003717652,0.00008950839,0.0002484198,0.00004404662,0.00003453624,0.0000515637,0.00060661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01978952,"threshold_uncertainty_score":0.9998624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0399140599266958,"score_gpt":0.2981273854771628,"score_spread":0.258213325550467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}