{"id":"W1993124591","doi":"10.1016/j.bbamem.2014.11.015","title":"Folding and stability of the aquaglyceroporin GlpF: Implications for human aqua(glycero)porin diseases","year":2014,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Stiftung Rheinland-Pfalz für Innovation; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Aquaporin; Transmembrane protein; Folding (DSP implementation); Biology; Porin; Protein folding; Membrane protein; Transmembrane domain; Protein structure; Integral membrane protein; Aquaporin 1; Cell biology; Biochemistry; Biophysics; Chemistry; Membrane; Gene; Water channel; Bacterial outer membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005686656,0.000703439,0.0009674039,0.001105187,0.0001740499,0.0007536734,0.0006002414,0.0008752258,0.001332782],"category_scores_gemma":[0.0006624421,0.0002048529,0.0002507432,0.001318244,0.0004676931,0.0009892762,0.0007139736,0.001125757,0.0008944119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005558335,"about_ca_system_score_gemma":0.0007755391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008038289,"about_ca_topic_score_gemma":0.001096007,"domain_scores_codex":[0.9998912,0.00001491982,0.00001627393,0.00002238093,0.00004105681,0.00001421744],"domain_scores_gemma":[0.9998325,0.0000636992,0.00003222388,0.000005569319,0.00004521932,0.00002082279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001313265,0.00003968844,0.0002692159,0.008626384,0.00009510489,0.0002592878,0.00004493345,0.0004554375,0.004152714,0.004586835,0.02586614,0.9554728],"study_design_scores_gemma":[0.00002204338,0.00006365156,0.0008819898,0.001366512,0.0001135248,0.001109148,0.00005064626,0.0001333565,0.001531864,0.002733195,0.9919738,0.00002025985],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002875941,0.9985332,0.0002285809,0.0003062495,0.0001442665,0.000002219665,0.00002403533,0.000006424167,0.0004672502],"genre_scores_gemma":[0.001326752,0.9976102,0.0002387719,0.0001681598,0.0001295878,0.000004014273,0.0000424769,0.000001805837,0.0004782677],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001332782,"threshold_uncertainty_score":0.004458606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0360049505347635,"score_gpt":0.3232302141623715,"score_spread":0.287225263627608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}