{"id":"W1993146774","doi":"10.1371/journal.pone.0086114","title":"Impact of ABCB1 and CYP2B6 Genetic Polymorphisms on Methadone Metabolism, Dose and Treatment Response in Patients with Opioid Addiction: A Systematic Review and Meta-Analysis","year":2014,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; St. Joseph’s Healthcare Hamilton; McMaster University; Population Health Research Institute","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Methadone; CYP2B6; Meta-analysis; Medicine; Confidence interval; Internal medicine; Methadone maintenance; Pharmacology; Opioid; CYP3A4; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0122494,0.00232038,0.01789164,0.006610597,0.0006543167,0.003259124,0.002102711,0.002570972,0.00321583],"category_scores_gemma":[0.03019814,0.00155978,0.03240753,0.008814099,0.0006399857,0.001544096,0.001351292,0.001525196,0.0003050929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002690524,"about_ca_system_score_gemma":0.003923317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008918773,"about_ca_topic_score_gemma":0.02009493,"domain_scores_codex":[0.9916963,0.003814243,0.002507133,0.0008162956,0.0009139031,0.0002521208],"domain_scores_gemma":[0.9777375,0.01651699,0.003477419,0.0004802189,0.001539448,0.0002483797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001364113,0.00003201831,0.005472588,0.3840433,0.5972739,0.0001563005,0.0001002208,0.0003666612,0.0002457807,0.00008534364,0.0005098046,0.01034989],"study_design_scores_gemma":[0.0003200211,0.0001458212,0.004432644,0.02500171,0.9685767,0.0001019608,0.00004365262,0.0001305115,0.00007687673,0.00009934661,0.001052215,0.00001866596],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00521364,0.9934081,0.0003165123,0.0001972111,0.0000980962,0.0002071526,0.0003604056,0.000015191,0.000183644],"genre_scores_gemma":[0.1690722,0.8255884,0.001991419,0.0008575689,0.0002544587,0.001076008,0.0007996345,0.00002582789,0.0003344567],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01789164,"threshold_uncertainty_score":0.06478179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07791534570186973,"score_gpt":0.3092892633076403,"score_spread":0.2313739176057706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}