{"id":"W1993159474","doi":"10.2337/db13-1522","title":"RFamide Peptides 43RFa and 26RFa Both Promote Survival of Pancreatic β-Cells and Human Pancreatic Islets but Exert Opposite Effects on Insulin Secretion","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"East China Institute of Technology; Ministero dell’Istruzione, dell’Università e della Ricerca; Compagnia di San Paolo; Sanofi","keywords":"Pancreatic islets; Internal medicine; Endocrinology; Insulin; Biology; Secretion; Protein kinase B; Apoptosis; Islet; Receptor; Kinase; Signal transduction; Cell biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540445,0.0004610777,0.00030579,0.0001556316,0.00009082032,0.0001731712,0.0001108069,0.000201092,0.001452212],"category_scores_gemma":[0.00010731,0.00009037755,0.0004105565,0.00008610798,0.0001531867,0.0001544997,0.0001302622,0.0004555182,0.0003256779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001125586,"about_ca_system_score_gemma":0.0001238607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002461789,"about_ca_topic_score_gemma":0.0002728174,"domain_scores_codex":[0.9998969,0.00001761092,0.00001187739,0.00002451591,0.00002082967,0.0000281844],"domain_scores_gemma":[0.9999264,0.00001138029,0.00002197791,0.000009072531,0.000007565773,0.00002363415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004486981,0.00003392294,0.000122854,0.00005165321,0.000009573873,0.0001213249,0.000008475189,0.00007641577,0.9973772,0.00004729137,0.00005323459,0.001649376],"study_design_scores_gemma":[0.0001116499,0.002022216,0.01089492,0.00001810329,0.00005139414,0.0009885894,0.00003997148,0.0002339524,0.9783639,0.00005670938,0.00720325,0.00001518784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924939,0.003066884,0.001432796,0.00009872657,0.00004598736,0.00003583074,0.000500716,0.00004296361,0.002282174],"genre_scores_gemma":[0.9880987,0.003454901,0.003498688,0.0001907762,0.00006902067,0.00006229803,0.001286398,0.00003223391,0.003306953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452212,"threshold_uncertainty_score":0.004858136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00934995341117366,"score_gpt":0.2284746376737841,"score_spread":0.2191246842626104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}