{"id":"W1993168446","doi":"10.1371/journal.pgen.1004390","title":"Glycogen Synthase Kinase (GSK) 3β Phosphorylates and Protects Nuclear Myosin 1c from Proteasome-Mediated Degradation to Activate rDNA Transcription in Early G1 Cells","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"King Abdullah International Medical Research Center; Vetenskapsrådet; Karolinska Institutet; University of Toronto; Cancerfonden","keywords":"Biology; GSK-3; Chromatin; P300-CBP Transcription Factors; GSK3B; Ubiquitin ligase; Molecular biology; Cell biology; Phosphorylation; Ubiquitin; Biochemistry; Histone Acetyltransferases; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005685,0.00039095,0.0002075646,0.0002579779,0.000133427,0.0002784432,0.0001510801,0.000162283,0.001332702],"category_scores_gemma":[0.00007776121,0.0001751467,0.0002660805,0.0001264096,0.0002232596,0.000126523,0.0002419543,0.0004155354,0.0004594211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000429043,"about_ca_system_score_gemma":0.0002903601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007889388,"about_ca_topic_score_gemma":0.001610165,"domain_scores_codex":[0.9999503,0.0000056449,0.000003735117,0.00001482622,0.000008971392,0.00001664125],"domain_scores_gemma":[0.9999391,0.000007104135,0.00002105924,0.00000743152,0.000004222819,0.00002108114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114202,0.00001047278,0.000419332,0.00003607004,0.000005258161,0.00004716864,0.000007624715,0.00007578641,0.9981318,0.0001039462,0.00005112486,0.001000128],"study_design_scores_gemma":[0.00004697197,0.0001634537,0.03296287,0.0000131776,0.00001733712,0.0002100006,0.00002983494,0.0009852867,0.9631059,0.0002100601,0.002248575,0.000006543655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924567,0.002746308,0.002398208,0.0001554536,0.00004036164,0.0000156432,0.0006547899,0.0001611947,0.001371454],"genre_scores_gemma":[0.9953441,0.0009938505,0.0009199652,0.00007179565,0.000008241776,0.00002072479,0.0006540926,0.00003170352,0.001955539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001332702,"threshold_uncertainty_score":0.004458308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005912772001182879,"score_gpt":0.1823005165365845,"score_spread":0.1763877445354016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}