{"id":"W1993203090","doi":"10.3109/03602532.2014.882354","title":"Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer’s disease","year":2014,"lang":"en","type":"review","venue":"Drug Metabolism Reviews","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"McMaster University","keywords":"Neurodegeneration; Fibril; Lipid raft; Amyloid (mycology); Chemistry; Membrane; Lipid bilayer; Toxicity; Biophysics; Amyloid disease; P3 peptide; Alzheimer's disease; Cell biology; Amyloid precursor protein; Biochemistry; Amyloid fibril; Biology; Medicine; Disease; Pathology; Amyloid β","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000499943,0.0004397247,0.0004065148,0.0007437678,0.0005729379,0.0003931265,0.0004408329,0.001174118,0.001793135],"category_scores_gemma":[0.0004258834,0.0003111363,0.0003242871,0.000448422,0.0003198122,0.0007489006,0.0005063099,0.001365727,0.0008279837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005783725,"about_ca_system_score_gemma":0.0004204586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00254122,"about_ca_topic_score_gemma":0.003141054,"domain_scores_codex":[0.9997051,0.00004346562,0.00001147217,0.00004826545,0.0001617057,0.00002994145],"domain_scores_gemma":[0.9998111,0.00006344376,0.00002901785,0.00001652425,0.00006474272,0.00001524457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000109884,0.0001121242,0.001673199,0.001254377,0.00007924998,0.0004256841,0.0002691511,0.001981824,0.90312,0.009092392,0.006955113,0.074927],"study_design_scores_gemma":[0.0001051744,0.0007331622,0.0257075,0.0009986082,0.0001868832,0.003126443,0.0006365323,0.05546102,0.612814,0.01485116,0.2852231,0.0001565156],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2948084,0.417495,0.1967197,0.008783519,0.002968497,0.000582254,0.001917626,0.001607655,0.0751174],"genre_scores_gemma":[0.6634418,0.1768326,0.1231887,0.002504384,0.0005644592,0.0006628997,0.00104913,0.0002197687,0.03153623],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00254122,"threshold_uncertainty_score":0.005998671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04560577052640799,"score_gpt":0.3771954562808686,"score_spread":0.3315896857544606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}