{"id":"W1993206064","doi":"10.1074/jbc.m110.189936","title":"Proprotein Convertase PC7 Enhances the Activation of the EGF Receptor Pathway through Processing of the EGF Precursor","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Heparin-binding EGF-like growth factor; Epidermal growth factor; Proprotein Convertases; Kexin; Cell biology; Transmembrane protein; Furin; Receptor; Biology; Transmembrane domain; Biochemistry; Chemistry; LDL receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502603,0.0004527623,0.0002119856,0.0003438409,0.00008249866,0.0003635818,0.0001657964,0.0002351849,0.001223505],"category_scores_gemma":[0.0002131744,0.00009589727,0.0003350466,0.0001493383,0.0001837565,0.0001737713,0.0002317235,0.00040655,0.0005539847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002175643,"about_ca_system_score_gemma":0.0002134831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004215074,"about_ca_topic_score_gemma":0.0004623441,"domain_scores_codex":[0.9998032,0.0000411104,0.00001272866,0.00001761243,0.00007888769,0.00004644986],"domain_scores_gemma":[0.9998581,0.00004136547,0.00001584344,0.00001176386,0.00003043322,0.00004243204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000089906,0.00003020488,0.0001192255,0.00002671343,0.000005550695,0.0000644359,0.000005782608,0.00002998978,0.9979897,0.00007512077,0.00002172764,0.001541702],"study_design_scores_gemma":[0.000006442921,0.0001832791,0.001509062,0.000002400432,0.00001128075,0.0001471267,0.000008737023,0.0003157648,0.9969335,0.00002746677,0.0008533762,0.000001638447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920849,0.001936512,0.00243206,0.00006553754,0.00002224043,0.00003784776,0.0001601083,0.00005685892,0.003203893],"genre_scores_gemma":[0.9919905,0.001459956,0.002792977,0.00004292712,0.00001846402,0.00002166874,0.0005768286,0.00002521214,0.003071494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223505,"threshold_uncertainty_score":0.004093051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260542544233472,"score_gpt":0.2245884638813904,"score_spread":0.1985342094580432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}