{"id":"W1993215622","doi":"10.1210/me.2005-0398","title":"Targeted Ablation of the Chromogranin A (Chga) Gene: Normal Neuroendocrine Dense-Core Secretory Granules and Increased Expression of Other Granins","year":2006,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Sherbrooke; McGill University; Royal Victoria Hospital","funders":"","keywords":"Chromogranin A; Biology; Prohormone convertase; Endocrinology; Internal medicine; Adrenal medulla; Enteroendocrine cell; Chromaffin cell; Secretion; Secretory protein; Granule (geology); Secretory Vesicle; Cell biology; Exocytosis; Endocrine system; Hormone; Catecholamine; Prohormone; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469913,0.0008172449,0.0003423869,0.0007018998,0.0001650883,0.0004120317,0.0004202412,0.0006935935,0.001568111],"category_scores_gemma":[0.0002544578,0.0003302352,0.0003391207,0.0002508816,0.001009726,0.0002985536,0.0003979325,0.0007795859,0.0005014251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004779329,"about_ca_system_score_gemma":0.0004072147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032699,"about_ca_topic_score_gemma":0.001557885,"domain_scores_codex":[0.9997141,0.00001789683,0.00003499103,0.00009221625,0.00008302435,0.00005763948],"domain_scores_gemma":[0.999625,0.0000565965,0.0001250481,0.00004361393,0.00002117937,0.0001285918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008882226,0.00001502131,0.0001300044,0.0000165877,0.000004456718,0.0001739626,0.000007504624,0.00004385479,0.9988253,0.0001391634,0.00002423028,0.000531168],"study_design_scores_gemma":[0.0001135048,0.0003293737,0.007283642,0.000009878662,0.00004524889,0.002181461,0.00003501502,0.001198877,0.9857833,0.0001798445,0.002825406,0.00001437344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992721,0.0009336121,0.004131231,0.0001524529,0.00007487549,0.00004313702,0.0007808518,0.0002494665,0.0009131969],"genre_scores_gemma":[0.9897083,0.0007530383,0.003862079,0.00007034257,0.00002173588,0.00005468993,0.0006903638,0.0001098801,0.004729568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568111,"threshold_uncertainty_score":0.005245864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005520214683040452,"score_gpt":0.1966398321531185,"score_spread":0.1911196174700781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}