{"id":"W1993215622","doi":"10.1210/me.2005-0398","title":"Targeted Ablation of the Chromogranin A (Chga) Gene: Normal Neuroendocrine Dense-Core Secretory Granules and Increased Expression of Other Granins","year":2006,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Sherbrooke; McGill University; Royal Victoria Hospital","funders":"","keywords":"Chromogranin A; Biology; Prohormone convertase; Endocrinology; Internal medicine; Adrenal medulla; Enteroendocrine cell; Chromaffin cell; Secretion; Secretory protein; Granule (geology); Secretory Vesicle; Cell biology; Exocytosis; Endocrine system; Hormone; Catecholamine; Prohormone; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005059838,0.0001903522,0.0002274178,0.00007897776,0.00006585924,0.000004319583,0.0001759936,0.00009232025,0.00002142629],"category_scores_gemma":[0.00002163665,0.0001618359,0.0001549304,0.0001150023,0.0002293482,0.00000489496,0.00007939296,0.0001088592,5.81813e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006331114,"about_ca_system_score_gemma":0.00003557701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004374195,"about_ca_topic_score_gemma":0.0001413373,"domain_scores_codex":[0.9987923,0.0001219786,0.0003357867,0.0003174287,0.0001612805,0.000271221],"domain_scores_gemma":[0.999298,0.00000982744,0.0001895579,0.0003834047,0.00007973052,0.0000395233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001466831,0.00006489472,0.04621552,0.00003851615,0.00002420305,0.00002840828,0.00002141342,0.0001277443,0.9528232,0.0003878156,0.0000239325,0.00009762766],"study_design_scores_gemma":[0.0009974663,0.0001560427,0.07260937,0.00001470648,0.00005101171,0.0001038691,0.000009501082,0.00006282031,0.9230072,0.0001412195,0.002711308,0.0001354812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932883,0.001700655,0.00436211,0.00003896308,0.00008680211,0.0002505372,0.00005323982,0.00001348692,0.0002058404],"genre_scores_gemma":[0.9986562,0.00006763052,0.0003625485,0.00007226255,0.00005616044,0.00001530565,0.0006844786,0.00003129708,0.00005413632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02981605,"threshold_uncertainty_score":0.6599475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005520214683040452,"score_gpt":0.1966398321531185,"score_spread":0.1911196174700781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}