{"id":"W1993231594","doi":"10.1016/j.exger.2004.06.020","title":"Mechanisms of the inhibitory effects of amyloid β-protein on synaptic plasticity","year":2004,"lang":"en","type":"article","venue":"Experimental Gerontology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland; Higher Education Authority","keywords":"Long-term potentiation; Synaptic plasticity; Neuroscience; Hippocampus; Neurotransmission; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Hippocampal formation; Amyloid (mycology); Alzheimer's disease; Biology; Chemistry; Biochemistry; Disease; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003352774,0.0001415987,0.0003104534,0.0000535407,0.00004941853,0.000001631743,0.0001001669,0.00008574872,0.00007538604],"category_scores_gemma":[0.00005421539,0.00009405829,0.0001308784,0.00006865686,0.0002834352,0.00002637208,0.00007051152,0.000114581,0.00003089757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001607277,"about_ca_system_score_gemma":0.0001309242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001431248,"about_ca_topic_score_gemma":0.000007795889,"domain_scores_codex":[0.9989808,0.00007602231,0.0001939603,0.0002011469,0.0003042474,0.0002438844],"domain_scores_gemma":[0.9994476,0.00006291864,0.00009045963,0.0002386038,0.00002972347,0.000130686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001181365,0.002796158,0.0003384262,0.0001278423,0.001945341,0.0001435971,0.0003206596,0.000006135887,0.981559,0.01142334,0.00002408766,0.0001340615],"study_design_scores_gemma":[0.003636356,0.003135128,0.006506559,0.0001926278,0.00009606275,0.00003009352,0.0001555712,0.000005023919,0.985459,0.0007201849,0.000001823871,0.0000616037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957811,0.002308468,0.0001067392,0.00009313305,0.0001393853,0.0007626843,0.000006288124,0.00001759701,0.0007845864],"genre_scores_gemma":[0.9995265,0.000002476112,0.0002508424,0.00007371009,0.00002108047,0.00008670718,0.000003428534,0.00001423973,0.00002102569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01070315,"threshold_uncertainty_score":0.3835586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0206313097851013,"score_gpt":0.3017726315577337,"score_spread":0.2811413217726324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}