{"id":"W1993264795","doi":"10.1371/journal.pone.0094188","title":"The Pro-Inflammatory Cytokine, Interleukin-6, Enhances the Polarization of Alternatively Activated Macrophages","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":317,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Crohn's and Colitis Foundation of Canada; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation","keywords":"Cytokine; Immunology; Macrophage polarization; Inflammation; STAT protein; Cell biology; Autocrine signalling; Biology; Interleukin 10; Immune system; Interleukin; Macrophage; Innate immune system; Tumor necrosis factor alpha; Interleukin 4; Signal transduction; STAT3; In vitro; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170818,0.000299055,0.0001983838,0.0001830528,0.00007663103,0.0002146056,0.00008997615,0.0001952084,0.001006799],"category_scores_gemma":[0.0001176722,0.00007736542,0.0002453157,0.00008039162,0.0001241601,0.0001743137,0.0001670212,0.0005984363,0.0002867822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006026771,"about_ca_system_score_gemma":0.0000920454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006204671,"about_ca_topic_score_gemma":0.0001220249,"domain_scores_codex":[0.9998167,0.00006144067,0.00001706844,0.00002650084,0.00004013121,0.00003810055],"domain_scores_gemma":[0.9998683,0.00002770555,0.00003046765,0.0000157653,0.00001727488,0.00004041821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001944822,0.00003531362,0.0001698969,0.0000327053,0.000002249058,0.00004643606,0.00001258083,0.00002246319,0.9984391,0.00002479771,0.00001249717,0.001007487],"study_design_scores_gemma":[0.00003493551,0.001017998,0.00436966,0.00001011861,0.00001784204,0.0004041217,0.00003526954,0.000478578,0.9918756,0.00005900101,0.001693749,0.000003110403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950641,0.001772551,0.001934143,0.0001057099,0.00004616237,0.00001785154,0.00009634525,0.00002089008,0.0009423457],"genre_scores_gemma":[0.9954304,0.001067812,0.002053683,0.0000748809,0.00003578511,0.00001684934,0.0001413066,0.000006431446,0.001172821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006799,"threshold_uncertainty_score":0.003368139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608074616387074,"score_gpt":0.2205109122279006,"score_spread":0.2044301660640299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}