{"id":"W1993264795","doi":"10.1371/journal.pone.0094188","title":"The Pro-Inflammatory Cytokine, Interleukin-6, Enhances the Polarization of Alternatively Activated Macrophages","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":317,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Crohn's and Colitis Foundation of Canada; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation","keywords":"Cytokine; Immunology; Macrophage polarization; Inflammation; STAT protein; Cell biology; Autocrine signalling; Biology; Interleukin 10; Immune system; Interleukin; Macrophage; Innate immune system; Tumor necrosis factor alpha; Interleukin 4; Signal transduction; STAT3; In vitro; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003587497,0.0001234467,0.0001836579,0.00003528354,0.0002495218,0.00001729221,0.0004770611,0.00009970552,0.0001311823],"category_scores_gemma":[0.0002380378,0.00007038176,0.00004408734,0.00009671568,0.000439442,0.00007509138,0.0001085919,0.0002759523,0.000132379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003393538,"about_ca_system_score_gemma":0.00003481271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003687172,"about_ca_topic_score_gemma":0.00001567725,"domain_scores_codex":[0.9989704,0.0003203689,0.0002669412,0.0001598769,0.00006921763,0.0002132232],"domain_scores_gemma":[0.9988059,0.0004136954,0.0002724973,0.0003518413,0.0001496944,0.000006362308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001273392,0.0001424234,0.0008464972,0.00003235005,0.0004406662,1.976005e-7,0.0004919142,0.000001583459,0.9947052,0.0008686869,0.0001570249,0.002186126],"study_design_scores_gemma":[0.000380837,0.0001080669,0.004971618,0.0000987588,0.00005426904,0.000001542648,0.00009819961,0.000013511,0.989626,0.0001972234,0.004367068,0.00008290745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957297,0.001385958,0.0001527785,0.0004880561,0.0003487168,0.0003232968,0.000009184019,0.00004495155,0.00151732],"genre_scores_gemma":[0.9944465,0.0002150482,0.00005694276,0.00008614593,0.00005614145,0.00004725441,0.00001486694,0.00001761162,0.005059536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005079193,"threshold_uncertainty_score":0.2870085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608074616387074,"score_gpt":0.2205109122279006,"score_spread":0.2044301660640299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}