{"id":"W1993282202","doi":"10.1089/10430340150218396","title":"Cytokine Gene Transfer Enhances Herpes Oncolytic Therapy in Murine Squamous Cell Carcinoma","year":2001,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Cancer Institute; American Cancer Society","keywords":"Oncolytic virus; Cytokine; Genetic enhancement; Herpes simplex virus; Cancer research; Virus; CD8; Immunotherapy; Biology; Immunology; Cytotoxic T cell; Cancer; Immune system; Virology; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000492975,0.0005026635,0.0004306568,0.000227998,0.0002075264,0.00006014527,0.0007088053,0.0002685566,0.0007496363],"category_scores_gemma":[0.000005327959,0.0004653526,0.0002338109,0.0003553811,0.000183923,0.0000125768,0.00005394163,0.0002269506,0.00004986155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007440932,"about_ca_system_score_gemma":0.000174797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001968185,"about_ca_topic_score_gemma":0.001115696,"domain_scores_codex":[0.9970555,0.0003037007,0.0005035351,0.0008593317,0.0004206628,0.0008572968],"domain_scores_gemma":[0.9986568,0.0000253638,0.0000670976,0.0009398489,0.0001198903,0.0001909726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00474317,0.0008092187,0.002096833,0.00001010191,0.00004432631,0.00008823985,0.000338119,0.0001442535,0.9738038,0.000004419873,0.0001817299,0.01773586],"study_design_scores_gemma":[0.007404273,0.009144587,0.00662475,0.000004920515,0.00000522914,0.00003372826,0.00004822436,0.00002368599,0.962537,0.00009755437,0.01353999,0.0005360718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984003,0.0136068,0.0001251383,0.0001610594,0.0001017962,0.0008167476,0.00002172493,0.00004598006,0.001117744],"genre_scores_gemma":[0.9863881,0.009531938,0.00009634805,0.000828026,0.0007301378,0.0001942203,0.0001728543,0.0001366189,0.001921774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01719978,"threshold_uncertainty_score":0.9997798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0284840913877305,"score_gpt":0.2973592015591203,"score_spread":0.2688751101713898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}