{"id":"W1993282202","doi":"10.1089/10430340150218396","title":"Cytokine Gene Transfer Enhances Herpes Oncolytic Therapy in Murine Squamous Cell Carcinoma","year":2001,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Cancer Institute; American Cancer Society","keywords":"Oncolytic virus; Cytokine; Genetic enhancement; Herpes simplex virus; Cancer research; Virus; CD8; Immunotherapy; Biology; Immunology; Cytotoxic T cell; Cancer; Immune system; Virology; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158188,0.0003613206,0.0002770799,0.000273954,0.00009147332,0.0003056725,0.0001272734,0.0002707196,0.0009337171],"category_scores_gemma":[0.0001416554,0.0001105591,0.0002082928,0.000174665,0.0001773071,0.0001981793,0.0001973521,0.0005297069,0.0002730211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002964332,"about_ca_system_score_gemma":0.0002240572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007402728,"about_ca_topic_score_gemma":0.0006748999,"domain_scores_codex":[0.9998174,0.00003346644,0.00001227019,0.00002559606,0.00006238268,0.0000488738],"domain_scores_gemma":[0.9999001,0.00002687885,0.00002254566,0.00001516747,0.00001503138,0.00002029058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009936158,0.00008966756,0.0001095269,0.00002068127,0.000003469509,0.00002388171,0.00001625197,0.0002021831,0.9977151,0.00007267632,0.00002161965,0.001625645],"study_design_scores_gemma":[0.00003211517,0.001107237,0.001045725,0.000004628486,0.00001374119,0.00009144712,0.00001124811,0.001103501,0.9955323,0.00003127828,0.001024565,0.00000213202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963068,0.0006368018,0.001377919,0.00003242787,0.00002357003,0.00005609021,0.0001475566,0.00004683331,0.001372165],"genre_scores_gemma":[0.995922,0.0004733972,0.001565689,0.00001535574,0.000008060142,0.00003252149,0.0001794594,0.00001395768,0.001789594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009337171,"threshold_uncertainty_score":0.003123581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0284840913877305,"score_gpt":0.2973592015591203,"score_spread":0.2688751101713898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}