{"id":"W1993293695","doi":"10.1186/s13395-015-0032-z","title":"Retinoic acid promotes myogenesis in myoblasts by antagonizing transforming growth factor-beta signaling via C/EBPβ","year":2015,"lang":"en","type":"article","venue":"Skeletal Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Case Western Reserve University","keywords":"Myogenesis; C2C12; Retinoic acid; Myocyte; Transcription factor; Cellular differentiation; Cell biology; Ccaat-enhancer-binding proteins; Biology; Retinoic acid receptor; Transforming growth factor; Internal medicine; Chemistry; Endocrinology; Molecular biology; Cell culture; Medicine; Nuclear protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000203189,0.000249673,0.0002299023,0.00006765025,0.00008764002,0.00001992737,0.0002329441,0.0002387718,0.00002909986],"category_scores_gemma":[0.00006597489,0.0002508598,0.0001227207,0.0001709023,0.0001068302,0.00001991609,0.00007328109,0.0001548924,0.00001746589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002319213,"about_ca_system_score_gemma":0.00007617741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009452435,"about_ca_topic_score_gemma":0.00006332158,"domain_scores_codex":[0.998495,0.0001055232,0.0002876861,0.0004898304,0.0001521714,0.0004697944],"domain_scores_gemma":[0.999451,0.0000148384,0.00007584297,0.0002358278,0.00006632484,0.0001561921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006085814,0.00009375937,0.002027908,0.00003738199,0.00002539917,0.000003993476,0.0002137653,0.00001540375,0.988966,0.00001795859,0.0001670986,0.008370405],"study_design_scores_gemma":[0.001022134,0.000411602,0.004414006,0.00002552743,0.00001320391,0.000005268707,0.0002385683,0.00006284336,0.9913129,0.0003018373,0.001795001,0.0003971761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960131,0.00144989,0.001224039,0.0001553657,0.0001326179,0.0002322472,0.00002528539,0.00003168756,0.0007357737],"genre_scores_gemma":[0.9991373,0.00005928751,0.0002177573,0.0001773859,0.0001228313,0.00003012586,0.000172293,0.00003825588,0.00004474381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00797323,"threshold_uncertainty_score":0.9999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314768659345244,"score_gpt":0.2363260114125747,"score_spread":0.2231783248191223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}