{"id":"W1993310369","doi":"10.1371/journal.pone.0099484","title":"Constitutive Androstane Receptor Ligands Modulate the Anti-Tumor Efficacy of Paclitaxel in Non-Small Cell Lung Cancer Cells","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo; Frederick National Laboratory for Cancer Research","keywords":"Paclitaxel; Lung cancer; Agonist; Cancer research; Inverse agonist; Cancer; Pharmacology; Cancer cell; Biology; Internal medicine; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640058,0.0002165899,0.0006818438,0.0001212162,0.00006935529,0.00001585776,0.0001646766,0.00008971474,0.0001167559],"category_scores_gemma":[0.0001493409,0.0001596563,0.0001138826,0.0002706179,0.0002931283,0.00005206874,0.00004234937,0.0002855808,0.00002325523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009786592,"about_ca_system_score_gemma":0.0002386394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005487489,"about_ca_topic_score_gemma":0.00005101462,"domain_scores_codex":[0.9985305,0.00008265994,0.0004155402,0.0003039131,0.0003131139,0.0003542753],"domain_scores_gemma":[0.9986822,0.0003578904,0.0002013898,0.0005017059,0.000150929,0.0001059067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001946315,0.002245766,0.03794031,0.0009431737,0.0002736312,0.00002842858,0.002192922,0.0000960912,0.9528104,0.00002572701,0.0006539472,0.0008432733],"study_design_scores_gemma":[0.005314331,0.0005295145,0.06076078,0.002216672,0.0005129708,0.00000755872,0.0002663326,0.002493345,0.9268521,0.000005299732,0.0007835159,0.0002575481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940811,0.003009398,0.00002244025,0.0005561548,0.0001266109,0.0009204639,0.00004207111,0.00002688142,0.001214877],"genre_scores_gemma":[0.9962771,0.001845276,0.000169753,0.0002693967,0.0002816356,0.00005818999,0.00001148894,0.00003247228,0.001054697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02595828,"threshold_uncertainty_score":0.6510595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582949188884777,"score_gpt":0.2355100801449616,"score_spread":0.2196805882561138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}