{"id":"W1993331667","doi":"10.1042/bj20091064","title":"A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4","year":2009,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Novo Nordisk Fonden; Novo Nordisk; Alberta Heritage Foundation for Medical Research; Eidgenössische Technische Hochschule Zürich; Terry Fox Foundation","keywords":"Protein disulfide-isomerase; Endoplasmic reticulum; Transmembrane domain; Transmembrane protein; ER retention; Biology; Cytoplasm; Calnexin; Biochemistry; Wild type; Cell biology; Subcellular localization; Thioredoxin; Membrane protein; Molecular biology; Mutant; Amino acid; Enzyme; Calreticulin; Membrane; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119553,0.0001261892,0.0001284311,0.00002089109,0.0001003059,0.00003106343,0.0003088744,0.00009850114,0.00002936888],"category_scores_gemma":[0.0002461886,0.00006830159,0.0001454309,0.0001713043,0.0000980997,0.000002992063,0.00004001164,0.0001325752,0.000003393833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001162489,"about_ca_system_score_gemma":0.00008507408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002699959,"about_ca_topic_score_gemma":9.825545e-7,"domain_scores_codex":[0.9991404,0.00005687397,0.0002533828,0.0001647971,0.0001833935,0.000201128],"domain_scores_gemma":[0.9993128,0.00001168874,0.00008848489,0.00027283,0.0001743304,0.0001398504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002729016,0.0001225689,0.001004309,0.000007979637,0.00004321638,0.000002778573,0.00003076485,0.0005064025,0.9698297,0.00009890554,0.02720125,0.0008792496],"study_design_scores_gemma":[0.0008357092,0.0001716662,0.004017615,0.0000529321,0.00007057971,0.00006137739,0.00004384177,0.0001815983,0.9773817,0.0002198038,0.01683892,0.0001242707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988265,0.002676995,0.003463709,0.004964126,0.0002270429,0.0001764823,0.00003500614,0.000004616841,0.0001869784],"genre_scores_gemma":[0.9978551,0.0001985545,0.00007400707,0.001425936,0.0002952209,0.000002756498,0.00003311925,0.000009046199,0.0001062433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01036232,"threshold_uncertainty_score":0.2785258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005320235756376594,"score_gpt":0.2361082804819664,"score_spread":0.2307880447255898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}