{"id":"W1993332077","doi":"10.1371/journal.ppat.1000493","title":"Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Science Centre for Human and Animal Health","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"IRF7; Ebola virus; Biology; Proinflammatory cytokine; Interferon; Virology; Innate immune system; Interferon regulatory factors; IRF3; Virus; Vesicular stomatitis virus; Interferon type I; Transcription factor; SUMO protein; Immune system; Immunology; Gene; Ubiquitin; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635207,0.0004257849,0.0002557878,0.0001426906,0.0001379678,0.0002725896,0.0002046854,0.0002605958,0.000558674],"category_scores_gemma":[0.00008896488,0.0001246919,0.0002838295,0.00009101626,0.0001970897,0.0001902248,0.0001665848,0.0004818196,0.0002093195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147796,"about_ca_system_score_gemma":0.0001410333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005512438,"about_ca_topic_score_gemma":0.0008212829,"domain_scores_codex":[0.99985,0.00003655735,0.00001645239,0.000023119,0.00003537728,0.0000384052],"domain_scores_gemma":[0.9999566,0.00001185651,0.00001028304,0.00000930532,0.00000516046,0.00000682978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002722974,0.00001474534,0.0001376891,0.00002152274,0.00000348325,0.00001867073,0.000005789292,0.00003658749,0.9989727,0.00007515741,0.000009994331,0.0006764793],"study_design_scores_gemma":[0.000008900167,0.0002072864,0.003047474,0.000006501548,0.00001182479,0.0001609395,0.00001704123,0.0008878926,0.9938258,0.00004370954,0.001779616,0.000003085231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992864,0.001719907,0.003526791,0.0000704563,0.00002052359,0.00003109056,0.0001482519,0.00004491452,0.001574095],"genre_scores_gemma":[0.9950641,0.0008129534,0.00291414,0.00003620366,0.000005299054,0.00001694637,0.0002700369,0.000008756933,0.0008715875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000558674,"threshold_uncertainty_score":0.001868963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04864522038658292,"score_gpt":0.3155740282721453,"score_spread":0.2669288078855624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}