{"id":"W1993332077","doi":"10.1371/journal.ppat.1000493","title":"Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Science Centre for Human and Animal Health","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"IRF7; Ebola virus; Biology; Proinflammatory cytokine; Interferon; Virology; Innate immune system; Interferon regulatory factors; IRF3; Virus; Vesicular stomatitis virus; Interferon type I; Transcription factor; SUMO protein; Immune system; Immunology; Gene; Ubiquitin; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002392674,0.0001369034,0.0001583061,0.00009542169,0.0002693282,0.00004273745,0.0000843646,0.00007736674,0.00007418183],"category_scores_gemma":[0.0002212763,0.00009342879,0.00006924009,0.0003342891,0.00004989329,0.00009708812,0.00002736941,0.0003519689,0.0001137719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009365383,"about_ca_system_score_gemma":0.00004019882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005550745,"about_ca_topic_score_gemma":0.00001166433,"domain_scores_codex":[0.9988772,0.00007309629,0.0002159298,0.0002950751,0.0002772664,0.0002614594],"domain_scores_gemma":[0.9992638,0.00002492755,0.0000634286,0.0003598223,0.0001990196,0.00008896151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112444,0.0003004478,0.001016111,0.00001599108,0.00002711168,0.000006597214,0.0002680748,0.000009401587,0.9758431,0.00003473983,0.002983243,0.01938279],"study_design_scores_gemma":[0.0008337732,0.00217314,0.03945773,0.000262689,0.0002704138,0.000173782,0.000917581,0.007874241,0.938505,0.0001904042,0.00891205,0.0004291969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916847,0.0003601327,0.0002673971,0.004662908,0.0001629955,0.0005051532,0.00001886814,0.0001339256,0.002203913],"genre_scores_gemma":[0.9961734,0.0002040697,0.00007615765,0.0003640162,0.000463622,0.00003003072,0.00008057027,0.00002146056,0.00258667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03844162,"threshold_uncertainty_score":0.3809915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04864522038658292,"score_gpt":0.3155740282721453,"score_spread":0.2669288078855624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}