{"id":"W1993336170","doi":"10.1016/j.bioorg.2008.08.005","title":"Fluorescent isotope-coded affinity tag (FCAT) I: Design and synthesis","year":2008,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Commission; Canadian Institute for Theoretical Astrophysics","keywords":"Chemistry; Fluorophore; Fluorescence; Reagent; Cysteine; Isotope; Reactivity (psychology); Linker; Combinatorial chemistry; Biochemistry; Enzyme; Organic chemistry; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007629106,0.0002351698,0.0002191815,0.00001137891,0.0002517281,0.00002141863,0.0002982827,0.0002254493,0.001095153],"category_scores_gemma":[0.0001279194,0.0002434287,0.0000612813,0.0001156075,0.0001681119,0.00005239774,0.0001449465,0.0002443921,0.00003201944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001043486,"about_ca_system_score_gemma":0.00008779601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001144044,"about_ca_topic_score_gemma":2.772522e-7,"domain_scores_codex":[0.9988655,0.000007706775,0.0002537131,0.0004491148,0.0001414508,0.0002825365],"domain_scores_gemma":[0.9989786,0.0001113539,0.0001179073,0.0005814004,0.00004891599,0.0001617917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001862007,0.0001128198,0.0003611323,0.00008237543,0.00001608529,0.000009339888,0.00003801571,0.000001422902,0.9969566,0.00003738768,0.001600547,0.0007656131],"study_design_scores_gemma":[0.0002287274,0.000003842993,0.00005456844,0.00003402203,0.00002058023,0.0001234858,0.00003326923,0.0001143551,0.9940382,0.0003953025,0.004665908,0.0002877225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746319,0.000531812,0.01670286,0.0003971259,0.00001326146,0.0002783054,0.00005627975,0.0006897637,0.006698675],"genre_scores_gemma":[0.9530218,0.0007501543,0.04443741,0.0000533547,0.0001319802,0.0002050941,0.00001947185,0.00005200329,0.001328722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02773455,"threshold_uncertainty_score":0.999818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333285095765819,"score_gpt":0.2307123157429878,"score_spread":0.2073794647853296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}