{"id":"W1993358922","doi":"10.1016/j.expneurol.2008.02.004","title":"A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice","year":2008,"lang":"nl","type":"article","venue":"Experimental Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute of Biomedical Innovation; Ministry of Health, Labour and Welfare","keywords":"Neuroprotection; Spinal cord; Amyotrophic lateral sclerosis; Microglia; SOD1; Medicine; Genetically modified mouse; Oxidative stress; Neuroscience; Transgene; Pharmacology; Endocrinology; Biology; Internal medicine; Superoxide dismutase; Inflammation; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325542,0.0006982018,0.0009079969,0.0004932278,0.0004036268,0.0003897294,0.0006074411,0.0006850646,0.00177323],"category_scores_gemma":[0.0001500155,0.0003569225,0.0004053954,0.0002502526,0.0005155174,0.0003854127,0.0002005067,0.001579468,0.000620177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004736983,"about_ca_system_score_gemma":0.0008607903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002343237,"about_ca_topic_score_gemma":0.00552997,"domain_scores_codex":[0.9997558,0.00003185075,0.00002753918,0.00003334332,0.00005044453,0.0001010434],"domain_scores_gemma":[0.9998281,0.00001237752,0.00004875087,0.00001303382,0.00001537199,0.0000823428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002163369,0.0006113052,0.0002297661,0.0001037025,0.00004754227,0.0001037921,0.00003462242,0.000189284,0.9928745,0.0001734701,0.0003813195,0.003087357],"study_design_scores_gemma":[0.000722311,0.006039775,0.006251841,0.00003107026,0.0001265474,0.0003999168,0.0001327224,0.002488573,0.9814956,0.0001801868,0.002103292,0.00002812857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961145,0.0008390027,0.0006920747,0.000252857,0.0000678259,0.00003800062,0.0004107661,0.000173293,0.001411815],"genre_scores_gemma":[0.9917876,0.001056311,0.001436617,0.0001606859,0.00003531625,0.0001053881,0.0007547478,0.00003825286,0.004625091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002343237,"threshold_uncertainty_score":0.005932093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04186121646328135,"score_gpt":0.344966001954907,"score_spread":0.3031047854916256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}