{"id":"W1993387783","doi":"10.1021/ac9010556","title":"Direct Analysis of Enzyme-Catalyzed DNA Demethylation","year":2009,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Biotechnology and Biological Sciences Research Council; Newton Fund; Wellcome Trust","keywords":"AlkB; Chemistry; DNA demethylation; DNA; Methyltransferase; Demethylation; DNA methylation; Biochemistry; Enzyme; Methylation; DNA repair; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005209101,0.0005132977,0.000432694,0.0005361161,0.0001784325,0.0003353057,0.0004762977,0.0004686402,0.002121544],"category_scores_gemma":[0.0009373231,0.000242011,0.0002519334,0.0005286887,0.0002221415,0.0003084742,0.000182336,0.001042998,0.0007875159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004714969,"about_ca_system_score_gemma":0.0004233967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001975789,"about_ca_topic_score_gemma":0.002759313,"domain_scores_codex":[0.9996254,0.00005356275,0.00002090175,0.00008696514,0.0001570623,0.00005608085],"domain_scores_gemma":[0.9992896,0.0002735019,0.00008732705,0.00005890429,0.0002128811,0.00007769452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000667003,0.00002686573,0.0003352346,0.00007186975,0.0000154902,0.00001548854,0.00002382375,0.0001064771,0.996511,0.0001373839,0.00003815474,0.002651577],"study_design_scores_gemma":[0.000003826826,0.00009711408,0.0008814768,0.000002192098,0.000009603178,0.0000279334,0.000007191646,0.0009644756,0.9972,0.00002904356,0.0007733979,0.000003686982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8755648,0.008542718,0.1045258,0.0001910746,0.00010733,0.0002793082,0.00337091,0.0005565642,0.006861671],"genre_scores_gemma":[0.9288729,0.005397181,0.05036246,0.00010032,0.00002426671,0.0002230002,0.003230153,0.0001040574,0.0116857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002121544,"threshold_uncertainty_score":0.007097244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01114868928862874,"score_gpt":0.2721998826390374,"score_spread":0.2610511933504087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}