{"id":"W1993399299","doi":"10.4161/15384101.2014.973321","title":"Human colonic fibroblasts regulate stemness and chemotherapy resistance of colon cancer stem cells","year":2014,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"China Scholarship Council; University of Toronto; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Clonogenic assay; Cancer stem cell; Biology; Cancer research; Stem cell; Cancer cell; Chemotherapy; Cancer; Tumor initiation; Tumor microenvironment; Cell biology; Cell; Metastasis; Tumor cells; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008764472,0.0001798141,0.0001479952,0.0002806623,0.0001660146,0.0003389232,0.00005602969,0.0001544143,0.001702363],"category_scores_gemma":[0.0001504616,0.00008377853,0.000140403,0.0001403818,0.000125177,0.0001029874,0.0001290614,0.0002648227,0.0003106783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002502755,"about_ca_system_score_gemma":0.0001984959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002144375,"about_ca_topic_score_gemma":0.003055631,"domain_scores_codex":[0.9999003,0.00002613176,0.000008523493,0.00001201868,0.00002583613,0.00002706886],"domain_scores_gemma":[0.9998848,0.00003620265,0.00002321404,0.00001445138,0.00001932064,0.00002190059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002270458,0.00003644301,0.0007889891,0.00003096976,0.000004805116,0.0001185471,0.00004813181,0.00008678222,0.9959202,0.0001243404,0.00010387,0.00250998],"study_design_scores_gemma":[0.0000308117,0.000336578,0.01396605,0.000007688414,0.00001623855,0.0003871047,0.0001154314,0.001157887,0.9799002,0.00009355212,0.003982261,0.000006188364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900171,0.004873529,0.001219878,0.0001380201,0.00003648597,0.00003147514,0.0003739147,0.00007160789,0.003237932],"genre_scores_gemma":[0.9960361,0.001183718,0.0005249124,0.00004547634,0.000007533901,0.00001564575,0.0002377501,0.000009522744,0.001939426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002144375,"threshold_uncertainty_score":0.005694985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009487576910878663,"score_gpt":0.253513873893372,"score_spread":0.2440262969824934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}